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首页> 外文期刊>Acta biomaterialia >Substrate geometry directs the in vitro mineralization of calcium phosphate ceramics.
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Substrate geometry directs the in vitro mineralization of calcium phosphate ceramics.

机译：基质的几何形状指导磷酸钙陶瓷的体外矿化。

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摘要

Repetitive concavities on the surface of bone implants have recently been demonstrated to foster bone formation when implanted at ectopic locations in vivo. The current study aimed to evaluate the effect of surface concavities on the surface mineralization of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) ceramics in vitro. Hemispherical concavities with different diameters were prepared at the surface of HA and β-TCP sintered disks: 1.8mm (large concavity), 0.8mm (medium concavity) and 0.4mm (small concavity). HA and β-TCP disks were sintered at 1100 or 1200°C and soaked in simulated body fluid for 28 days at 37°C; the mineralization process was followed by scanning electron microscopy, energy-dispersive spectroscopy, X-ray diffraction and calcium quantification analyses. The results showed that massive mineralization occurred exclusively at the surface of HA disks treated at 1200°C and that nucleation of large aggregates of calcium phosphate started specifically inside small concavities instead of on the planar surface of the disks. Regarding the effect of concavity diameter size on surface mineralization, it was observed that small concavities induce 124- and 10-fold increased mineralization compared to concavities of large or medium size, respectively. The results of this study demonstrated that (i) in vitro surface mineralization of calcium phosphate ceramics with surface concavities starts preferentially within the concavities and not on the planar surface, and (ii) concavity size is an effective parameter to control the spatial position and extent of mineralization in vitro.
机译：最近已证明，在体内异位植入时，骨植入物表面的重复性凹面会促进骨形成。当前的研究旨在评估表面凹度对体外羟基磷灰石（HA）和β-磷酸三钙（β-TCP）陶瓷表面矿化的影响。在HA和β-TCP烧结盘的表面制备了不同直径的半球形凹面：1.8mm（大凹面），0.8mm（中凹面）和0.4mm（小凹面）。 HA和β-TCP圆盘在1100或1200°C烧结，并在37°C的模拟体液中浸泡28天;矿化过程之后是扫描电子显微镜，能量分散光谱，X射线衍射和钙定量分析。结果表明，大量的矿化仅发生在经过1200°C处理的HA圆盘的表面，并且大的磷酸钙聚集体的成核作用特别是在小凹面内开始，而不是在圆盘的平面上开始。关于凹坑直径大小对表面矿化的影响，观察到与大或中等大小的凹坑相比，小凹坑分别引起成矿增加124倍和10倍。这项研究的结果表明：（i）具有表面凹面的磷酸钙陶瓷的体外表面矿化作用优先在凹面内而不是在平面上开始;（ii）凹面尺寸是控制空间位置和范围的有效参数。体外矿化作用。

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