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首页> 外文期刊>Acta biomaterialia >Synthesis and viscoelastic characterization of novel hydrogels generated via photopolymerization of 1,2-epoxy-5-hexene modified poly(vinyl alcohol) for use in tissue replacement.
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Synthesis and viscoelastic characterization of novel hydrogels generated via photopolymerization of 1,2-epoxy-5-hexene modified poly(vinyl alcohol) for use in tissue replacement.

机译：通过1,2-环氧-5-己烯改性的聚乙烯醇的光聚合生成的新型水凝胶的合成和粘弹性表征，用于组织替代。

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摘要

Hydrogels have been proposed as candidates for tissue replacement; however, current systems are often highly susceptible to hydrolytic degradation and have not been shown to mimic the viscoelastic behavior of the native tissue when subjected to dynamic loading conditions. In the present work, 1,2-epoxy-5-hexene modified poly(vinyl alcohol) was crosslinked via photopolymerization to generate non-degradable hydrogels with mechanical properties and network characteristics that could be modulated through variation in the type and percentage of a monomeric additive. Complex shear moduli obtained from dynamic frequency sweeps in torsional shear were used to exemplify the differences in the viscoelastic behavior of the materials, and the corresponding changes in crosslink density were determined by rubber elasticity theory. Hydrolysis resistance was assessed by monitoring variations in the moduli of hydrogels submerged in Hank's balanced salt solution for progressively longer periods of time. Over the time-frame of the experiment, no change in the viscoelastic behavior was observed. Direct contact assays and elution tests were used to demonstrate that the system was non-cytotoxic. This study represents a successful attempt to generate a non-degradable hydrogel system with viscoelastic behavior that can be readily modulated to match that of soft biological tissues for use in tissue replacement.
机译：已经提出水凝胶可以替代组织。然而，当前的系统通常高度易受水解降解的影响，并且在动态负荷条件下还没有表现出模仿天然组织的粘弹性行为的能力。在目前的工作中，1,2-环氧-5-己烯改性的聚乙烯醇通过光聚合反应交联生成具有机械特性和网络特性的不可降解水凝胶，可以通过改变单体的类型和百分比来对其进行调节添加剂。从扭转剪切的动态频率扫描获得的复数剪切模量用于举例说明材料的粘弹性行为的差异，并通过橡胶弹性理论确定了相应的交联密度变化。通过监测逐渐浸入汉克平衡盐溶液中的水凝胶的模量变化，评估其耐水解性，持续时间更长。在实验的时间范围内，没有观察到粘弹性行为的变化。直接接触分析和洗脱测试用于证明该系统无细胞毒性。这项研究代表了成功的尝试，以产生一种具有粘弹性行为的不可降解的水凝胶体系，该体系可以很容易地调节以匹配软生物组织的组织，用于组织替代。

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