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首页> 外文期刊>Acta biomaterialia >Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties
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Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties

机译：用于骨骼替代的磷酸钙水泥：化学，处理和机械性能

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摘要

Since their initial formulation in the 1980s, calcium phosphate cements (CPCs) have been increasingly used as bone substitutes. This article provides an overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties. Many processing parameters, such as particle size, composition of cement reactants and additives, can be adjusted to control the setting process of CPCs, concomitantly influencing their handling and mechanical performance. Moreover, this review shows that, although the mechanical strength of CPCs is generally low, it is not a critical issue for their application for bone repair - an observation not often realized by researchers and clinicians. CPCs with compressive strengths comparable to those of cortical bones can be produced through densification and/or homogenization of the cement matrix. The real limitation for CPCs appears to be their low fracture toughness and poor mechanical reliability (Weibull modulus), which have so far been only rarely studied.
机译：自1980年代最初配制以来，磷酸钙水泥（CPC）越来越多地用作骨替代品。本文概述了用于骨替代的CPC的化学，凝固动力学和处理特性（凝固时间，内聚性和可注射性），并重点介绍了其机械性能。可以调节许多加工参数，例如粒度，水泥反应物和添加剂的组成，以控制CPC的凝结过程，从而影响其处理和机械性能。此外，该评论表明，尽管CPC的机械强度通常较低，但对于其在骨修复中的应用而言并不是关键问题-研究人员和临床医生通常不会意识到这一点。通过水泥基体的致密化和/或均质化，可以产生具有与皮质骨相当的抗压强度的CPC。 CPC的真正局限性似乎是其低的断裂韧性和较差的机械可靠性（Weibull模量），到目前为止，很少进行研究。

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