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首页> 外文期刊>Acta Cardiologica >Conventional and non-conventional coronary risk factors in male premature coronary artery disease patients already having a low Framingham risk score.
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Conventional and non-conventional coronary risk factors in male premature coronary artery disease patients already having a low Framingham risk score.

机译：男性早产冠心病患者的传统和非常规冠心病危险因素已经具有较低的Framingham风险评分。

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BACKGROUND: Individual risk factors and, more importantly, global risk assessment tools such as the Framingham risk score have been used successfully for risk prediction especially in older patients. However, there is paucity of data about the coronary heart disease prediction in premature coronary artery disease patients with a low Framingham risk score. METHODS AND RESULTS: We recruited 102 consecutive young patients without hypertension and diabetes mellitus in the study. All subjects had had chest pain and underwent coronary angiography since non-invasive diagnostic test results suggested ischaemia. Forty-five patients having at least one coronary lesion independent of severity were included in the study group.The remaining fifty-seven subjects without any coronary lesion were used as control group. Conventional and non-conventional risk factors were evaluated both in patients and control subjects. Framingham risk score and absolute 10-year hard CHD events risk were also calculated for each individual. The coronary heart disease group had a significantly higher smoking frequency as compared to the control group.They also had higher plasma levels of triglycerides, apolipoprotein B and apo B/AI ratio but a smaller LDL particle size.We failed to find any independent CHD predictor after logistic regression analysis. However, individual ROC curve analysis of risk factors revealed that apolipoprotein B, triglycerides and apo B/AI ratio have the highest area under the curve for coronary artery disease prediction. CONCLUSIONS: The Framingham risk score may underestimate the true risk of an individual. Incorporating non-conventional risk factors such as apolipoprotein B and apo B/apo AI ratio may provide valuable information in these patients.
机译：背景：个体风险因素，更重要的是，全球风险评估工具（例如Framingham风险评分）已成功用于风险预测，尤其是在老年患者中。但是，关于弗雷明汉风险评分低的早发冠心病患者，关于冠心病预测的数据很少。方法和结果：我们连续招募了102名没有高血压和糖尿病的年轻患者。所有受试者均患有胸痛并接受了冠状动脉造影检查，因为非侵入性诊断测试结果提示缺血。研究组包括45例至少有1个独立于严重程度的冠状动脉病变的患者。其余57例无任何冠状动脉病变的受试者被用作对照组。在患者和对照组中均评估了常规和非常规危险因素。还计算了每个人的弗雷明汉风险评分和10年硬性冠心病绝对事件风险。冠心病组的吸烟频率明显高于对照组，血浆甘油三酸酯，载脂蛋白B和载脂蛋白B / AI的比例较高，但LDL粒径较小，我们未能找到任何独立的CHD预测因子经过逻辑回归分析。然而，对危险因素进行的单独ROC曲线分析显示，载脂蛋白B，甘油三酸酯和载脂蛋白B / AI比在曲线下面积最大，可预测冠状动脉疾病。结论：Framingham风险评分可能低估了个人的真实风险。纳入非常规的危险因素，例如载脂蛋白B和载脂蛋白B /载脂蛋白AI比率可能为这些患者提供有价值的信息。

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