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Influence of calcium ion deposition on apatite-inducing ability of porous titanium for biomedical applications.

机译:钙离子沉积对生物医学应用中多孔钛磷灰石诱导能力的影响。

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In the present study, the influence of calcium ion deposition on the apatite-inducing ability of porous titanium (Ti) was investigated in a modified simulated body fluid (m-SBF). Calcium hydroxide (Ca(OH)(2)) solutions with five degrees of saturation were used to hydrothermally deposit Ca ions on porous Ti with a porosity of 80%. Apatite-inducing ability of the Ca-ion-deposited porous Ti was evaluated by soaking them in m-SBF for up to 14 days. Scanning electron microscopy (SEM) and X-ray diffractometry (XRD) confirmed that a thin layer of calcium titanate (CaTiO(3))/calcium oxide (CaO) mixture with a nanostructured porous network was produced on porous Ti substrates after hydrothermal treatment at 200 degrees C for 8 h. X-ray photoelectron spectroscopy results demonstrated that the content of the Ca ions deposited on Ti and the thickness of the CaTiO(3)/CaO layer increased with increasing saturation degree of the Ca(OH)(2) solution. The thickest (over 10 nm) CaTiO(3)/CaO layer with the highest Ca content was achieved on the Ti treated in an oversaturated Ca(OH)(2) solution (0.2 M). SEM, XRD, transmission electron microscopy and Fourier transformed infrared spectroscopy analysis indicated that the porous Ti samples deposited with the highest content of Ca ions exhibited the best apatite-inducing ability, producing a dense and complete carbonated apatite coating after a 14 day soaking in m-SBF. The present study illustrated the validity of using Ca ion deposition as a pre-treatment to endow desirable apatite-inducing ability of porous Ti for bone tissue engineering applications.
机译:在本研究中,研究了在改良的模拟体液(m-SBF)中钙离子沉积对多孔钛(Ti)的磷灰石诱导能力的影响。具有五个饱和度的氢氧化钙(Ca(OH)(2))溶液用于将Ca离子水热沉积在孔隙率为80%的多孔Ti上。通过将钙离子沉积的多孔Ti在m-SBF中浸泡长达14天来评估磷灰石的诱导能力。扫描电子显微镜(SEM)和X射线衍射(XRD)证实,经过水热处理后,在多孔Ti基板上产生了具有纳米结构多孔网络的钛酸钙(CaTiO(3))/氧化钙(CaO)混合物薄层。 200摄氏度,持续8小时。 X射线光电子能谱结果表明,沉积在Ti上的Ca离子的含量和CaTiO(3)/ CaO层的厚度随着Ca(O​​H)(2)溶液饱和度的增加而增加。在过饱和的Ca(OH)(2)溶液(0.2 M)中处理的Ti上获得了具有最高Ca含量的最厚(超过10 nm)的CaTiO(3)/ CaO层。 SEM,XRD,透射电子显微镜和傅里叶变换红外光谱分析表明,沉积的Ca离子含量最高的多孔Ti样品具有最佳的磷灰石诱导能力,在m中浸泡14天后产生致密而完整的碳酸盐磷灰石涂层。 -SBF。本研究说明了使用Ca离子沉积作为预处理来赋予骨组织工程应用所需的多孔Ti磷灰石诱导能力的有效性。

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