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首页> 外文期刊>Acta biomaterialia >Preparation and characterization of homogeneous chitosan-polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties.
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Preparation and characterization of homogeneous chitosan-polylactic acid/hydroxyapatite nanocomposite for bone tissue engineering and evaluation of its mechanical properties.

机译：用于骨组织工程的均相壳聚糖-聚乳酸/羟基磷灰石纳米复合材料的制备与表征及其力学性能评估。

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摘要

Homogeneous nanocomposites composed of hydroxyapatite and chitosan in the presence of polylactic acid were synthesized by a novel in situ precipitation method. The morphological and compositional properties of composites were investigated. Hydroxyapatite nanoparticles in a special rod-like shape with a diameter of about 50nm and a length of about 300nm were distributed homogeneously within the chitosan-polylactic acid matrix. The interaction between the organic matrix and the inorganic crystallite and the formation mechanism of the rod-like nanoparticles were also studied. The results suggested that the formation of the special rod-like nanoparticles could be controlled by a multiple-order template effect. High-resolution images showed that the rod-like inorganic particles were composed of randomly orientated subparticles about 10nm in diameter. The mechanical properties of the composites were evaluated by measuring their compressive strength and elastic modulus. The data indicated that the addition of polylactic acid can make homogeneous composites scaffold resist significantly higher stress. The elastic modulus of the composites was also improved by the addition of polylactic acid, which can make them more beneficial for surgical applications.
机译：通过一种新颖的原位沉淀法，合成了由羟基磷灰石和壳聚糖组成的均相纳米复合材料。研究了复合材料的形貌和组成特性。具有约50nm直径和约300nm长度的特殊棒状形状的羟基磷灰石纳米颗粒均匀地分布在壳聚糖-聚乳酸基质内。还研究了有机基体与无机微晶之间的相互作用以及棒状纳米颗粒的形成机理。结果表明，可以通过多阶模板效应来控制特殊棒状纳米颗粒的形成。高分辨率图像显示，棒状无机颗粒由直径约10nm的随机取向的亚颗粒组成。通过测量其抗压强度和弹性模量来评估复合材料的机械性能。数据表明，聚乳酸的添加可以使均质复合材料支架抵抗明显更高的应力。通过添加聚乳酸还可以提高复合材料的弹性模量，这可以使其更有利于外科应用。

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