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首页> 外文期刊>Acta biomaterialia >Diffusion of soluble factors through degradable polymer nerve guides: Controlling manufacturing parameters.
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Diffusion of soluble factors through degradable polymer nerve guides: Controlling manufacturing parameters.

机译：可降解因子通过可降解的聚合物神经导管扩散：控制制造参数。

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摘要

Nerve guides are cylindrical conduits of either biologically based or synthetic materials that are used to bridge nerve defects. While it is well known that a critical aspect of nerve regeneration is the delivery of oxygen and nutrients to the surviving nerve tissue, several guide parameters that determine the permeability of nerve guides to nutrients are often overlooked. We have reproducibly manufactured poly(caprolactone) (PCL) nerve guides of tailored porosity percentage, wall thickness and pore diameter through a dip-coating/salt-leaching technique. In this study, these three parameters were varied to measure the response of glucose and lysozyme diffusion through the guide wall. In addition, nerve guide permeability following protein fouling studies was examined. Based on the results from this study, it was determined that at high porosity percentages (80%), decreasing the pore diameter (10-38microm) was a measurable method of decreasing the lysozyme permeability of PCL nerve guides while not creating a loss of glucose permeability. PCL fouling studies were used to fine-tune the desirable nerve guide wall thickness. Results indicated that nerve guides 0.6mm thick decreased the loss of lysozyme to almost 10% without significantly diminishing glucose (nutrient) permeability. These results will be utilized to optimize nerve guide parameters for future in vivo applications.
机译：神经导向器是用于桥接神经缺损的基于生物或合成材料的圆柱形导管。众所周知，神经再生的一个关键方面是向存活的神经组织输送氧气和养分，但常常忽略了一些确定神经导游对养分通透性的指导参数。我们已经通过浸涂/盐浸技术可复制地制造了具有特定孔隙率，壁厚和孔径的聚己内酯（PCL）神经导管。在这项研究中，改变了这三个参数以测量葡萄糖和溶菌酶通过引导壁扩散的反应。另外，检查了蛋白质污染研究之后的神经引导渗透性。根据这项研究的结果，可以确定在高孔隙率（80％）时，减小孔径（10-38μm）是一种可降低PCL神经导管溶菌酶通透性而又不造成葡萄糖损失的可测量方法渗透性。 PCL结垢研究用于微调所需的神经引导壁厚度。结果表明，厚度为0.6mm的神经引导器将溶菌酶的损失降低到几乎10％，而葡萄糖（营养）的通透性却没有明显降低。这些结果将用于优化神经导向参数，以用于将来的体内应用。

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