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首页> 外文期刊>Acta biomaterialia >Porous composite scaffolds based on gelatin and partially hydrolyzed alpha-tricalcium phosphate.
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Porous composite scaffolds based on gelatin and partially hydrolyzed alpha-tricalcium phosphate.

机译：基于明胶和部分水解的α-磷酸三钙的多孔复合支架。

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摘要

Porous composite scaffolds of varying compositions were prepared by freeze-drying gelatin foams containing increasing amounts of alpha-tricalcium phosphate (alpha-TCP), up to about 40 wt.%. Due to the presence of gelatin, a partial hydrolysis of alpha-TCP into octacalcium phosphate (OCP) occurs during foaming. As a consequence, the scaffolds contain both alpha-TCP and OCP, in relative amounts of about 74% and 26%, respectively, independent of the initial composition. In physiological conditions the inorganic component of the scaffolds undergoes a further hydrolysis as shown by the finding that after immersion in phosphate-buffered saline at 37 degrees C for 1 week the scaffolds contain poorly crystalline hydroxyapatite together with OCP. The scaffolds display a porous interconnected microstructure. The mean dimensions of the pores decrease from about 350 to about 170 microm as the inorganic phase content increases. Simultaneously, the mean values of the compression strength and Young's modulus increase. Stabilization of the scaffolds was obtained by using a natural, non-toxic, crosslinking agent, genipin, which significantly improves their mechanical properties.
机译：通过冻干含有增加量的至多约40重量％的α-磷酸三钙（α-TCP）的明胶泡沫来制备具有不同组成的多孔复合支架。由于存在明胶，因此在发泡过程中会发生α-TCP部分水解为磷酸八钙（OCP）的现象。结果，支架包含α-TCP和OCP，相对量分别为约74％和26％，而与初始组成无关。在生理条件下，如发现在37℃的磷酸盐缓冲盐水中浸泡1周后，支架中含有较弱的结晶性羟基磷灰石和OCP，表明支架的无机成分进一步水解。支架显示出多孔的互连微结构。随着无机相含量的增加，孔的平均尺寸从约350微米降低至约170微米。同时，抗压强度和杨氏模量的平均值增加。支架的稳定化是通过使用天然的，无毒的交联剂京尼平（Genipin）来实现的，它可以显着改善其机械性能。

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