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首页> 外文期刊>Acta biomaterialia >Tissue anti-adhesion potential of biodegradable PELA electrospun membranes.
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Tissue anti-adhesion potential of biodegradable PELA electrospun membranes.

机译：可生物降解的PELA电纺膜的组织抗粘附潜力。

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摘要

The most commonly used anti-adhesion device for separation and isolation of wounded tissues after surgery is the polymeric membrane. In this study, a new anti-adhesion membrane from polylactide-polyethylene glycol tri-block copolymer (PELA) has been synthesized. The synthesized copolymers were characterized by gel permeation chromatography and (1)H nuclear magnetic resonance spectroscopy. PELA membrane was prepared by electrospun. The prepared copolymer membranes were more flexible than the control poly-d-l-lactic acid (PDLLA) membrane, as investigated by the measurements of glass transition temperature. Its biocompatibility and anti-adhesion capabilities were also evaluated. In vitro cell adhesions on the PELA copolymer membrane and PDLLA membrane were compared by the culture of mouse fibroblasts L929 on the surfaces. For in vivo evaluation of tissue anti-adhesion potential, the PDLLA and PELA copolymer membranes were implanted between cecum and peritoneal wall defects of rats and their tissue adhesion extents were compared. It was observed that the PELA copolymer membrane was very effective in preventing cell or tissue adhesion on the membrane surface, probably owing to the effects of hydrophilic polyethylene glycol.
机译：手术后用于分离和隔离受伤组织的最常用抗粘连设备是聚合物膜。在这项研究中，合成了一种由聚丙交酯-聚乙二醇三嵌段共聚物（PELA）制成的新型防粘膜。通过凝胶渗透色谱法和（1）H核磁共振谱对合成的共聚物进行表征。通过电纺丝制备PELA膜。通过玻璃化转变温度的测量，所制备的共聚物膜比对照聚-d-1-乳酸（PDLLA）膜更具柔韧性。还评估了其生物相容性和抗黏附能力。通过在表面上培养小鼠成纤维细胞L929来比较PELA共聚物膜和PDLLA膜上的体外细胞粘附。为了体内评估组织的抗粘附能力，将PDLLA和PELA共聚物膜植入大鼠的盲肠和腹膜壁缺损之间，并比较它们的组织粘附程度。观察到，PELA共聚物膜在防止细胞或组织在膜表面上的粘附方面非常有效，这可能是由于亲水性聚乙二醇的作用。

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