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首页> 外文期刊>Acta biomaterialia >Systematic strontium substitution in hydroxyapatite coatings on titanium via micro-arc treatment and their osteoblast/osteoclast responses.
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Systematic strontium substitution in hydroxyapatite coatings on titanium via micro-arc treatment and their osteoblast/osteoclast responses.

机译：通过微弧处理钛上羟基磷灰石涂层中的系统锶替代及其成骨/破骨细胞反应。

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摘要

This study attempts to enhance the osseointegration of titanium implants by adopting a micro-arc treatment (MAT) capable of replacing calcium (Ca) with different percentages of strontium (Sr) in order to fabricate strontium-containing hydroxyapatite (Sr-HAp) coatings. Sr, regarded as a significant therapy promoting bone mass and bone strength, has a dual mechanism, enhancing osteoblast differentiation and inhibiting osteoclast differentiation. This study also investigates how Sr content affects the microstructure of and osteoblast/osteoclast growth on the coatings. Experimental results indicate that an increase in the Sr content in the electrolyte bath results in a greater degree of Sr substitution at Ca sites within the HAp phase, facilitating the formation of Sr-HAp coatings with Sr fully solid soluble in the HAp phase. Irrespective of the Sr content, most coatings are similar in porous morphology and pore size. Additionally, the Sr-HAp coating shows higher osteoblast compatibility than raw titanium metal and the HAp coating. Moreover, cell adhesion and proliferation after 48 h was greater than that after 4 h, indicating that Sr can stimulate osteoblast adhesion and proliferation. Further, Sr significantly inhibits osteoclast differentiation when the Sr-HAp coatings exceed 38.9 at.% Sr.
机译：这项研究试图通过采用微弧处理（MAT）来增强钛植入物的骨整合，该微弧处理能够用不同百分比的锶（Sr）代替钙（Ca），从而制造含锶的羟基磷灰石（Sr-HAp）涂层。 Sr被认为是促进骨量和骨强度的重要疗法，它具有双重机制，可增强成骨细胞分化并抑制破骨细胞分化。这项研究还研究了Sr含量如何影响涂层的微结构以及成骨细胞/破骨细胞的生长。实验结果表明，电解液中Sr含量的增加会导致HAp相中Ca位置的Sr取代程度更高，从而促进了Sr-HAp涂层的形成，其中Sr完全固溶在HAp​​相中。不论Sr含量如何，大多数涂层的孔隙形态和孔径均相似。另外，Sr-HAp涂层显示出比原始钛金属和HAp涂层更高的成骨细胞相容性。此外，48h后的细胞黏附和增殖大于4h后，表明Sr可以刺激成骨细胞黏附和增殖。另外，当Sr-HAp涂层超过38.9原子％Sr时，Sr显着抑制破骨细胞分化。

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