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首页> 外文期刊>Acta biomaterialia >Nanostructure and mineral composition of trabecular bone in the lateral femoral neck: implications for bone fragility in elderly women.
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Nanostructure and mineral composition of trabecular bone in the lateral femoral neck: implications for bone fragility in elderly women.

机译：股骨外侧颈小梁骨的纳米结构和矿物质组成：对老年女性骨脆性的影响。

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Despite interest in investigating age-related hip fractures, the determinants of decreased bone strength in advanced age are not clear enough. Hitherto it has been obscure how the aging process affects the femoral neck nanostructure and composition, particularly in the lateral subregion of the femoral neck, which is considered as a fracture-initiating site. The femoral bone samples used in this study were obtained at autopsy in 10 women without skeletal disease (five younger: aged 20-40 years, and five elderly: aged 73-94 years). Atomic force microscopy (AFM) was applied to explore the mineral grain size in situ in young vs. old trabecular bone samples from the lateral femoral neck. The chemical compositions of the samples were determined using inductively coupled plasma optical emission spectroscopy and direct current argon arc plasma optical emission spectrometry. Our AFM study revealed differences in trabecular bone nanostructure between young and elderly women. The mineral grain size in the trabeculae of the old women was larger than that in the young (median: 95 vs. 59nm), with a particular bimodal distribution: 45% were small grains (similar to the young) and the rest were larger. Since chemical analyses showed that levels of calcium and phosphorus were unchanged with age, our study suggests that during aging the existing bone mineral is reorganized and forms larger aggregates. Given the mechanical disadvantage of large-grained structures (decreased material strength), the observed nanostructural differences contribute to our understanding of the increased fragility of the lateral femoral neck in aged females. Moreover, increasing data on mineral grains in natural bone is essential for advancing calcium-phosphate ceramics for bone tissue replacement.
机译：尽管有兴趣研究与年龄有关的髋部骨折，但高龄时骨强度下降的决定因素还不够清楚。迄今为止，还不清楚老化过程如何影响股骨颈的纳米结构和组成，特别是在股骨颈的外侧子区域中，该区域被认为是骨折的起始部位。本研究中使用的股骨样品是在10例无骨骼疾病的妇女（5岁以下：20-40岁，五岁：73-94岁）中进行尸检时获得的。原子力显微镜（AFM）用于探究股骨外侧颈的年轻小骨与老小骨的原位矿物质粒径。使用电感耦合等离子体发射光谱法和直流氩弧等离子体发射光谱法测定样品的化学成分。我们的AFM研究显示，年轻女性和老年女性的小梁骨纳米结构存在差异。老年妇女的小梁中的矿物质晶粒尺寸大于年轻妇女（中位数：95 vs. 59nm），并且具有特殊的双峰分布：小晶粒（与年轻人相似）为45％，其余的较大。由于化学分析表明钙和磷的水平随年龄而变化，我们的研究表明，在衰老过程中，现有的骨矿物质会重新组织并形成较大的聚集体。考虑到大晶粒结构的机械缺陷（材料强度降低），观察到的纳米结构差异有助于我们理解老年女性股骨颈外侧的脆性增加。此外，增加天然骨中矿物质的数据对于推进磷酸钙陶瓷用于骨组织替代至关重要。

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