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首页> 外文期刊>Acta biomaterialia >New antibiotic-eluting mesh used for soft tissue reinforcement.
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New antibiotic-eluting mesh used for soft tissue reinforcement.

机译：用于软组织增强的新型抗生素洗脱网。

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摘要

The surgical implantation of prostheses for soft tissue repair may be followed by post-operative mesh-related infection, a significant and dramatic complication, that is treated by mesh removal. A new antibiotic-eluting mesh has been manufactured on pre-existing polypropylene prostheses using an airbrush spraying technology. Among the degradable polymers tested as coating agents and drug reservoirs, poly(epsilon-caprolactone) (PCL), which is deposited after heating, provides a homogeneous, regular and smooth shell around the polypropylene filaments of the mesh without dramatically altering the biomechanical properties of the new modified mesh. An anti-infective drug (e.g. ofloxacin) is incorporated into this polymeric coating giving a limited burst effect followed by sustained drug diffusion for several days. An ofloxacin-eluting mesh has demonstrated excellent antibacterial activity in vitro on Escherichia coli adherence, biofilm formation and inhibitory diameter, even with low drug loads. Although further in vivo investigations are required to draw conclusions on the anti-infective effectiveness of the coated mesh, the airbrush coating of ofloxacin-PCL on existing prostheses is already potentially appealing in an effort to decrease post-operative infection.
机译：外科植入假体进行软组织修复后，可能会发生术后网状相关感染，这是一种显着且戏剧性的并发症，可通过去除网来治疗。使用喷枪喷涂技术在现有的聚丙烯假体上制造了一种新的抗生素洗脱网。在测试过的可降解聚合物作为涂层剂和药物储库中，加热后沉积的聚（ε-己内酯）（PCL）可在网状聚丙烯细丝周围提供均匀，规则且光滑的外壳，而不会显着改变滤网的生物力学性能。新的修改后的网格。将抗感染药（例如氧氟沙星）掺入该聚合物涂层中，以提供有限的破裂效果，随后持续药物扩散几天。氧氟沙星洗脱网片在体外对大肠杆菌的粘附，生物膜形成和抑制直径均显示出优异的抗菌活性，即使在低药物负荷下也是如此。尽管需要进一步的体内研究得出涂层网的抗感染效果的结论，但是氧氟沙星-PCL在现有假体上的喷枪涂层在减少术后感染方面已经具有潜在的吸引力。

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