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首页> 外文期刊>Acta biomaterialia >Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery
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Amphiphilic block co-polymers: Preparation and application in nanodrug and gene delivery

机译：两亲性嵌段共聚物：纳米药物和基因传递的制备与应用

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摘要

Self-assembly of amphiphilic block co-polymers composed of poly(ethylene oxide) (PEO) as the hydrophilic block and poly(ether)s, poly(amino acid)s, poly(ester)s and polypropyleneoxide (PPO) as the hydrophobic block can lead to the formation of nanoscopic structures of different morphologies. These structures have been the subject of extensive research in the past decade as artificial mimics of lipoproteins and viral vectors for drug and gene delivery. The aim of this review is to provide an overview of the synthesis of commonly used amphiphilic block co-polymers. It will also briefly go over some pharmaceutical applications of amphiphilic block co-polymers as ?nanodelivery systems? for small molecules and gene therapeutics.
机译：两亲嵌段共聚物的自组装，该共聚物由作为亲水性嵌段的聚环氧乙烷（PEO）和作为疏水性的聚醚，聚氨基酸，聚酯和聚环氧丙烷（PPO）组成嵌段可以导致形成不同形态的纳米结构。在过去的十年中，这些结构作为脂蛋白的人工模拟物以及用于药物和基因递送的病毒载体，已经成为广泛研究的主题。这篇综述的目的是概述常用的两亲性嵌段共聚物的合成。它还将简要介绍两亲性嵌段共聚物作为“阳极递送系统”的一些医药应用。用于小分子和基因疗法。

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