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Advanced functional polymers for medicine: Multifunctional biomaterials

机译:医药用高级功能聚合物:多功能生物材料

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Innovative therapeutic concepts such as regenerative therapies require polymeric biomaferials with multiple functions. The complex requirements presented by these therapies cannot be fulfilled completely by the few polymers established in clinical applications so far. One of the major challenges for the polymeric materials community is to design multifunctional materials with functions such as degradability [1-3], controlled drug release capability [4], or stimuli-sensitivity [5], while addressing how to overcome immunological barriers [6], inflammation [7], or endotoxin contamination [8]. In order to bridge the gap between medical grade material availability and material demand, there needs to be clear communication between the scientists who design and produce polymeric materials and those that implement them in the bio-medical application and finally in the clinic.
机译:创新的治疗概念,例如再生疗法,需要具有多种功能的高分子生物材料。迄今为止,在临床应用中建立的几种聚合物无法完全满足这些疗法提出的复杂要求。聚合物材料界面临的主要挑战之一是设计功能多样的多功能材料,例如降解性[1-3],受控药物释放能力[4]或刺激敏感性[5],同时解决如何克服免疫学障碍[ 6],发炎[7]或内毒素污染[8]。为了弥合医学级材料可用性和材料需求之间的差距,需要在设计和生产聚合物材料的科学家与在生物医学应用以及最终在临床中实现聚合物材料的科学家之间进行清晰的沟通。

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