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首页> 外文期刊>Acta biomaterialia >Chitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration.
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Chitosan/bioactive glass nanoparticle composite membranes for periodontal regeneration.

机译：用于牙周再生的壳聚糖/生物活性玻璃纳米颗粒复合膜。

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摘要

Barrier membranes are used in periodontal applications with the aim of supporting periodontal regeneration by physically blocking migration of epithelial cells. The present work proposes a combination of chitosan (CHT) with bioactive glass nanoparticles (BG-NPs) in order to produce a novel guided tissue and bone regeneration membrane, fabricated by solvent casting. The CHT/BG-NP nanocomposite membranes are characterized in terms of water uptake, in mechanical tests, under simulated physiological conditions and in in vitro bioactivity tests. The addition of BG-NPs to CHT membranes decreased the mechanical potential of these membranes, but on the other hand the bioactivity improved. The membranes containing the BG-NPs induced the precipitation of bone-like apatite in simulated body fluid (SBF). Biological tests were carried out using human periodontal ligament cells and human bone marrow stromal cells. CHT/BG-NP composite membranes promoted cell metabolic activity and mineralization. The results indicate that the CHT/BG-NP composite membrane could potentially be used as a temporary guided tissue regeneration membrane in periodontal regeneration, with the possibility to induce bone regeneration.
机译：屏障膜用于牙周应用中，其目的是通过物理阻断上皮细胞的迁移来支持牙周再生。本工作提出了壳聚糖（CHT）与生物活性玻璃纳米颗粒（BG-NPs）的组合，以生产通过溶剂浇铸制造的新型引导组织和骨再生膜。 CHT / BG-NP纳米复合膜在机械测试，模拟生理条件下和体外生物活性测试中均以吸水为特征。向CHT膜中添加BG-NP降低了这些膜的机械潜能，但另一方面，生物活性得到了改善。含有BG-NPs的膜诱导了模拟体液（SBF）中骨状磷灰石的沉淀。使用人牙周膜细胞和人骨髓基质细胞进行了生物学测试。 CHT / BG-NP复合膜促进细胞代谢活性和矿化。结果表明，CHT / BG-NP复合膜可潜在地用作牙周再生中的临时引导组织再生膜，并有可能诱导骨再生。

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