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首页> 外文期刊>Acta biomaterialia >Development and evaluation of tetrapod-shaped granular artificial bones
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Development and evaluation of tetrapod-shaped granular artificial bones

机译：四脚形颗粒状人造骨的开发与评价

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We have developed a novel form of granular artificial bone ?Tetrabones? with a homogeneous tetrapod shape and uniform size. Tetrabones are four armed structures that accumulate to form the intergranular pores that allow invasion of cells and blood vessels. In this study we evaluated the physicochemical characteristics of Tetrabones in vitro, and compared their biological and biomechanical properties in vivo to those of conventional β-tricalcium phosphate (β-TCP) granule artificial bone. Both the rupture strength and elastic modulus of Tetrabone particles were higher than those of β-TCP granules in vitro. The connectivity of intergranular pores 100, 300, and 400 μm in size were higher in Tetrabones than in the β-TCP granules. Tetrabones showed similar osteoconductivity and biomechanical stiffness to β-TCP at 2 months after implantation in an in vivo study of canine bone defects. These results suggest that Tetrabones may be a good bone graft material in bone reconstruction.
机译：我们开发了一种新型的颗粒状人造骨“四骨”。具有均匀的四脚架形状和均匀的大小。四骨是四个武装的结构，积累起来形成沿晶间的孔，允许细胞和血管的入侵。在这项研究中，我们评估了四肢骨的体外理化特性，并将其在体内的生物学和生物力学特性与传统的β-磷酸三钙（β-TCP）颗粒人工骨进行了比较。在体外，Tetrabone颗粒的断裂强度和弹性模量均高于β-TCP颗粒。四元骨中的粒间孔100、300和400μm的连通性高于β-TCP颗粒。在犬骨缺损的体内研究中，四骨在植入后两个月显示出与β-TCP相似的骨传导性和生物力学刚度。这些结果表明，四骨骨可能是骨重建中良好的骨移植材料。

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