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首页> 外文期刊>Acta biomaterialia >Influence of the pore generator on the evolution of the mechanical properties and the porosity and interconnectivity of a calcium phosphate cement
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Influence of the pore generator on the evolution of the mechanical properties and the porosity and interconnectivity of a calcium phosphate cement

机译：造孔剂对磷酸钙水泥力学性能演变以及孔隙度和互连性的影响

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摘要

Porosity and interconnectivity are important properties of calcium phosphate cements (CPCs) and bone-replacement materials. Porosity of CPCs can be achieved by adding polymeric biodegradable pore-generating particles (porogens), which can add porosity to the CPC and can also be used as a drug-delivery system. Porosity affects the mechanical properties of CPCs, and hence is of relevance for clinical application of these cements. The current study focused on the effect of combinations of polymeric mesoporous porogens on the properties of a CPC, such as specific surface area, porosity and interconnectivity and the development of mechanical properties. CPC powder was mixed with different amounts of PLGA porogens of various molecular weights and porogen sizes. The major factors affecting the properties of the CPC were related to the amount of porogen loaded and the porogen size; the molecular weight did not show a significant effect per se. A minimal porogen size of 40 μm in 30 wt.% seems to produce a CPC with mechanical properties, porosity and interconnectivity suitable for clinical applications. The properties studied here, and induced by the porogen and CPC, can be used as a guide to evoke a specific host-response to maintain CPC integrity and to generate an explicit bone ingrowth.
机译：孔隙率和互连性是磷酸钙水泥（CPC）和骨替代材料的重要特性。 CPC的孔隙率可以通过添加聚合物可生物降解的造孔颗粒（致孔剂）来实现，这可以增加CPC的孔隙率，也可以用作药物递送系统。孔隙度影响CPC的机械性能，因此与这些水泥的临床应用有关。当前的研究集中在聚合物介孔致孔剂组合对CPC性能的影响上，例如比表面积，孔隙率和互连性以及机械性能的发展。将CPC粉末与不同量的各种分子量和成孔剂的PLGA致孔剂混合。影响CPC性能的主要因素与成孔剂的负载量和成孔剂的大小有关。分子量本身没有显示出明显的作用。在30 wt。％中最小的成孔剂尺寸为40μm，似乎会产生具有适用于临床应用的机械性能，孔隙率和互连性的CPC。此处研究的，由致孔剂和CPC诱导的特性可以用作引发特定宿主反应的指南，以维持CPC完整性并产生明确的骨长入。

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