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首页> 外文期刊>Acta biomaterialia >In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal
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In vitro and in vivo studies on a Mg-Sr binary alloy system developed as a new kind of biodegradable metal

机译：作为新型可生物降解金属的Mg-Sr二元合金系统的体外和体内研究

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Magnesium alloys have shown potential as biodegradable metallic materials for orthopedic applications due to their degradability, resemblance to cortical bone and biocompatible degradation/corrosion products. However, the fast corrosion rate and the potential toxicity of their alloying element limit the clinical application of Mg alloys. From the viewpoint of both metallurgy and biocompatibility, strontium (Sr) was selected to prepare hot rolled Mg-Sr binary alloys (with a Sr content ranging from 1 to 4 wt.%) in the present study. The optimal Sr content was screened with respect to the mechanical and corrosion properties of Mg-Sr binary alloys and the feasibility of the use of Mg-Sr alloys as orthopedic biodegradable metals was investigated by in vitro cell experiments and intramedullary implantation tests. The mechanical properties and corrosion rates of Mg-Sr alloys were dose dependent with respect to the added Sr content. The as-rolled Mg-2Sr alloy exhibited the highest strength and slowest corrosion rate, suggesting that the optimal Sr content was 2 wt.%. The as-rolled Mg-2Sr alloy showed Grade I cytotoxicity and induced higher alkaline phosphatase activity than the other alloys. During the 4 weeks implantation period we saw gradual degradation of the as-rolled Mg-2Sr alloy within a bone tunnel. Micro-computer tomography and histological analysis showed an enhanced mineral density and thicker cortical bone around the experimental implants. Higher levels of Sr were observed in newly formed peri-implant bone compared with the control. In summary, this study shows that the optimal content of added Sr is 2 wt.% for binary Mg-Sr alloys in the rolled state and that the as-rolled Mg-2Sr alloy in vivo produces an acceptable host response.
机译：镁合金由于其可降解性，与皮质骨的相似性和生物相容性降解/腐蚀产物而显示出了作为骨科应用的可生物降解金属材料的潜力。但是，其合金元素的快速腐蚀速率和潜在毒性限制了镁合金的临床应用。从冶金学和生物相容性两方面考虑，在本研究中选择锶（Sr）制备热轧Mg-Sr二元合金（Sr含量为1-4 wt。％）。根据Mg-Sr二元合金的机械和腐蚀性能筛选了最佳Sr含量，并通过体外细胞实验和髓内植入试验研究了将Mg-Sr合金用作骨科生物可降解金属的可行性。 Mg-Sr合金的机械性能和腐蚀速率与添加的Sr含量有关，与剂量有关。轧制后的Mg-2Sr合金具有最高的强度和最慢的腐蚀速率，表明最佳的Sr含量为2 wt。％。轧制的Mg-2Sr合金显示出I级细胞毒性，并比其他合金具有更高的碱性磷酸酶活性。在植入的4周期间，我们看到了骨隧道内已轧制的Mg-2Sr合金逐渐降解。微型计算机断层扫描和组织学分析显示，实验植入物周围的矿物质密度增加，皮质骨变厚。与对照组相比，在新形成的种植体周围骨中观察到更高的Sr水平。总而言之，这项研究表明，对于二元Mg-Sr合金，在轧制状态下Sr的最佳添加量为2 wt。％，并且铸态的Mg-2Sr合金在体内产生可接受的主体反应。

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