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首页> 外文期刊>Acta biomaterialia >Bone ingrowth in macroporous Bonelike for orthopaedic applications.
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Bone ingrowth in macroporous Bonelike for orthopaedic applications.

机译：大孔骨状骨的向内生长，用于整形外科。

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摘要

The aim of this study was to evaluate the biological behaviour of porous scaffold structures of Bonelike which is suitable for either direct clinical use or tissue engineering applications. Porous cylindrical specimens 8x10mm were implanted in the lateral aspect of the tibia of 13 patients (mean age 54 years), during osteotomy surgery for the treatment of medial compartment osteoarthritis of the knee. Implanted cylinders were retrieved at the same time as the removal of the blade plates at 3, 6, 9 and 12 months. Scanning electron microscopy and histological evaluations were performed to observe the biological responses of human bone tissue to porous Bonelike. The penetration depth was determined for all implantation periods, and after 6 months it was already possible to see new bone in the centre of the implanted cylinders, which gives 100% of penetration depth for all implantations periods except for 3 months when bone could only be seen in the peripherical region. Regarding the percentage of the areacovered by new bone calculated from two-dimensional histological sections, values of 53+/-15, 76+/-12 and 88+/-9% were achieved for 6, 9 and 12 months, respectively. Due to its structural features porous Bonelike permitted effective vascularization and bone ingrowth, and therefore was fully osteointegrated as shown in the histological surveys. A slow biomaterial degradation with implantation time is envisaged since the material has displayed surface degradation. Bonelike scaffolds show potential for complete ingrowth of osseous tissue and restoration of vascularization throughout the defected site.
机译：这项研究的目的是评估适用于直接临床应用或组织工程应用的Bonelike多孔支架结构的生物学行为。截骨手术期间，在13例胫骨外侧植入了8x10mm的多孔圆柱体标本（平均年龄54岁），用于治疗膝关节内侧室关节炎。在3、6、9和12个月取下刀片板的同时，取出植入的圆柱体。进行扫描电子显微镜和组织学评估以观察人骨组织对多孔骨样的生物学反应。确定所有植入时期的穿透深度，并且在6个月后已经有可能在植入圆柱体的中心看到新的骨头，这为所有植入时期提供了100％的穿透深度，但3个月内只能植入骨头在外围区域看到。根据二维组织学切片计算，新骨覆盖面积的百分比分别在6、9和12个月达到53 +/- 15、76 +/- 12和88 +/- 9％。由于其结构特征，多孔的骨状骨允许有效的血管形成和骨向内生长，因此，如组织学检查所示，骨被完全整合。由于材料已显示出表面降解，因此设想了随着植入时间的缓慢生物材料降解。骨样支架显示出骨组织完全向内生长并在整个缺损部位恢复血管化的潜力。

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