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首页> 外文期刊>Acta biomaterialia >Nucleation and growth of apatite on NaOH-treated PEEK, HDPE and UHMWPE for artificial cornea materials.
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Nucleation and growth of apatite on NaOH-treated PEEK, HDPE and UHMWPE for artificial cornea materials.

机译：NaOH处理的PEEK，HDPE和UHMWPE上用于人造角膜材料的磷灰石成核和生长。

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摘要

The skirt of an artificial cornea must integrate the implant to the host sclera, a major failure of present devices. Thus, it is highly desirable to encourage the metabolic activity of the cornea by using more bioactive, flexible skirt materials. Here we describe attempts to increase the bioactivity of polyether ether ketone (PEEK), high-density polyethylene (HDPE) and ultra-high molecular weight polyethylene (UHMWPE) films. The effectiveness of different strength NaOH pre-treatments to initiate apatite deposition on PEEK, HDPE and UHMWPE is investigated. We find that exposure of PEEK, HDPE and UHMWPE films to NaOH solutions induces the formation of potential nuclei for apatite (calcium phosphate), from which the growth of an apatite coating is stimulated when subsequently immersing the polymer films in 1.5 strength Simulated Body Fluid (SBF). As immersion time in SBF increases, further nucleation and growth produces a thicker and more compact apatite coating that can be expected to be highly bioactive. Interestingly, the apatite growth is found to also be dependent on both the concentration of NaOH solution and the structure of the polymer surface.
机译：人工角膜的裙边必须将植入物整合到宿主巩膜中，这是当前装置的主要故障。因此，非常希望通过使用更具生物活性的，柔性的裙边材料来促进角膜的代谢活性。在这里，我们描述了增加聚醚醚酮（PEEK），高密度聚乙烯（HDPE）和超高分子量聚乙烯（UHMWPE）膜的生物活性的尝试。研究了不同强度的NaOH预处理在PEEK，HDPE和UHMWPE上引发磷灰石沉积的有效性。我们发现，将PEEK，HDPE和UHMWPE膜暴露于NaOH溶液中会诱导形成磷灰石（磷酸钙）的潜在核，当随后将聚合物膜浸入1.5强度的模拟体液中时，会刺激磷灰石涂层的生长（ SBF）。随着在SBF中的浸入时间增加，进一步的成核和生长会产生更厚，更致密的磷灰石涂层，可以预期具有很高的生物活性。有趣的是，发现磷灰石的生长还取决于NaOH溶液的浓度和聚合物表面的结构。

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