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首页> 外文期刊>Acta biomaterialia >Drug release behavior of chitosan-montmorillonite nanocomposite hydrogels following electrostimulation.
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Drug release behavior of chitosan-montmorillonite nanocomposite hydrogels following electrostimulation.

机译：电刺激后壳聚糖-蒙脱土纳米复合水凝胶的药物释放行为。

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Nanocomposites hydrogel (nanohydrogel) composed of chitosan (CS) and montmorillonite (MMT) were prepared and systematically studied for drug release behavior following electrostimulation. The deterioration of the responsiveness and reversibility of CS upon repeated on-off electrostimulation switching operations are major limitations for clinical applications, as it suffers from too much structural instability for the precise control of the release of drug upon cyclic electrostimulation. To overcome these limitations, an inorganic phase, MMT, was incorporated in the CS matrix to enhance the anti-fatigue property and corresponding long-term stable release kinetics. X-ray diffraction analysis and time-dependent optical absorbance showed that the MMT incorporated into the nanohydrogel exhibited an exfoliated nanostructure. The exfoliated silica nanosheets are able to act as cross-linkers to form a network structure between the CS and MMT, and this difference in the cross-linking density strongly affects the release of vitamin B(12) under electrostimulation. With a lower MMT concentration (1wt.%), the release kinetics of vitamin B(12) from the nanohydrogel shows a pseudo-zero-order release, and the release mechanism was changed from a diffusion-controlled mode to a swelling-controlled mode under electrostimulation. Further increasing the MMT content reduced both the diffusion exponent n and the responsiveness of the nanohydrogel to electrostimulation. In addition, a consecutively repeated "on" and "off" operation shows that the electroresponsiveness of the nanohydrogel with higher MMT concentrations was reduced, but its anti-fatigue behavior was considerably improved. In this work, the nanohydrogel with 2wt.% MMT achieved a mechanically reliable and practically desirable pulsatile release profile and excellent anti-fatigue behavior, compared with that of the pure CS.
机译：制备了由壳聚糖（CS）和蒙脱石（MMT）组成的纳米复合水凝胶（nanohydrogel），并系统地研究了电刺激后的药物释放行为。反复进行开-关电刺激切换操作后，CS的响应性和可逆性变差是临床应用的主要局限性，因为它遭受太多的结构不稳定，无法精确控制循环电刺激后的药物释放。为了克服这些限制，将无机相MMT掺入CS基质中以增强抗疲劳性能和相应的长期稳定释放动力学。 X射线衍射分析和随时间变化的吸光度表明，掺入纳米水凝胶中的MMT表现出剥落的纳米结构。剥落的二氧化硅纳米片能够充当交联剂，从而在CS和MMT之间形成网络结构，这种交联密度的差异会强烈影响电刺激下维生素B（12）的释放。在较低的MMT浓度（1wt。％）下，维生素B（12）从纳米水凝胶的释放动力学显示出伪零级释放，并且释放机理从扩散控制模式变为溶胀控制模式在电刺激下。进一步增加MMT含量降低了扩散指数n和纳米水凝胶对电刺激的响应性。此外，连续重复的“开”和“关”操作表明，MMT浓度较高的纳米水凝胶的电响应性降低，但其抗疲劳性能得到显着改善。在这项工作中，与纯CS相比，具有2 wt。％MMT的纳米水凝胶实现了机械上可靠且实用上令人满意的脉动释放曲线和出色的抗疲劳性能。

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