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首页> 外文期刊>Acta biomaterialia >Dynamic mechanical behavior of starch-based scaffolds in dry and physiologically simulated conditions: Effect of porosity and pore size.
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Dynamic mechanical behavior of starch-based scaffolds in dry and physiologically simulated conditions: Effect of porosity and pore size.

机译：淀粉基支架在干燥和生理模拟条件下的动态力学行为：孔隙率和孔径的影响。

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The three-dimensional scaffolds of a blend of starch and poly(l-lactic) acid, SPLA70, were produced using compression molding of polymer/salt mixture followed by leaching of salt. One series of scaffolds were prepared with varying polymer-to-salt ratio while keeping the salt size constant, and the other series of scaffolds were prepared with varying salt sizes while keeping the polymer-to-salt ratio constant. The X-ray microcomputed tomography and scanning electron microscopy assay were used to analyze the porous morphologies, porosity and distribution of porosity of the porous scaffolds. Salt-free and integrated SPLA70 scaffolds with porosities ranging from 74% to 82% and pore sizes of 125-250 to 500-1000mum can be fabricated using the present fabrication technique. The water uptake of the SPLA70 scaffolds increases with increasing porosities and also with increasing pore size. In dry state, the storage modulus decreases with increasing porosity and also with increasing pore size. The normalized modulus values are related to normalized density of the scaffolds by a power-law function with an exponent between 2 and 3. For the immersed scaffolds under physiological conditions, the storage modulus was less dependent on porosity and pore size. However, the loss factor increased significantly compared with dry state measurements. The present study clearly shows that the mechanical performance of porous polymeric constructs in dry and in immersed state is completely different, and for comparison with biomechanical performance of tissues, the tests should ideally be performed in immersed state.
机译：淀粉和聚（乳酸）混合物SPLA70的三维支架是通过聚合物/盐混合物的压模成型，然后浸出盐来生产的。在保持盐尺寸不变的情况下，制备了一系列具有不同的聚合物与盐的比率的支架，而在保持聚合物盐比不变的情况下，制备了具有变化的盐大小的另一系列的支架。用X射线计算机断层扫描和扫描电子显微镜法分析了多孔支架的多孔形态，孔隙率和孔隙分布。可以使用本发明的制造技术来制造孔隙率范围为74％至82％，孔径为125-250至500-1000mum的无盐且集成的SPLA70支架。 SPLA70支架的吸水率随孔隙率的增加以及孔径的增加而增加。在干燥状态下，储能模量随着孔隙率的增加以及孔径的增加而降低。归一化模量值通过幂律函数与指数在2到3之间的幂定律函数与支架的归一化密度相关。对于在生理条件下浸没的支架，储能模量对孔隙度和孔径的依赖性较小。但是，与干态测量相比，损耗因子显着增加。本研究清楚地表明，多孔聚合物结构在干燥和浸入状态下的机械性能完全不同，并且为了与组织的生物力学性能进行比较，理想的测试应在浸入状态下进行。

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