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首页> 外文期刊>Acta biomaterialia >Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration.
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Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration.

机译：具有高强度和可降解性的自固化生物活性钙镁磷酸钙水泥，可用于骨骼再生。

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Calcium phosphate cement (CPC) has been successfully used in clinics as bone repair biomaterial for many years. However, poor mechanical properties and a low biodegradation rate limit any further applications. Magnesium phosphate cement (MPC) is characterized by fast setting, high initial strength and relatively rapid degradation in vivo. In this study, MPC was combined with CPC to develop novel calcium-magnesium phosphate cement (CMPC). The setting time, compressive strength, phase composition of hardened cement, degradation in vitro, cells responses in vitro by MG-63 cell culture and tissue responses in vivo by implantation of CMPC in bone defect of rabbits were investigated. The results show that CMPC has a shorter setting time and markedly better mechanical properties than either CPC or MPC. Moreover, CMPC showed significantly improved degradability compared to CPC in simulated body fluid. Cell culture results indicate that CMPC is biocompatible and could support cell attachment and proliferation. To investigate the in vivo biocompatibility and osteogenesis, the CMPC samples were implanted into bone defects in rabbits. Histological evaluation showed that the introduction of MPC into CPC enhanced the efficiency of new bone formation. CMPC also exhibited good biocompatibility, biodegradability and osteoconductivity with host bone in vivo. The results obtained suggest that CMPC, having met the basic requirements of bone tissue engineering, might have a significant clinical advantage over CPC, and may have the potential to be applied in orthopedic, reconstructive and maxillofacial surgery.
机译：磷酸钙水泥（CPC）多年来已在临床上成功用作骨修复生物材料。然而，差的机械性能和低的生物降解速率限制了任何进一步的应用。磷酸镁水泥（MPC）的特点是凝固速度快，初始强度高，体内降解相对较快。在这项研究中，MPC与CPC结合开发了新型钙镁磷酸钙水泥（CMPC）。研究了固化时间，抗压强度，硬化水泥的相组成，体外降解，MG-63细胞体外培养的细胞反应以及CMPC植入兔骨缺损体内的组织反应。结果表明，与CPC或MPC相比，CMPC的凝固时间更短，机械性能明显更好。此外，与模拟体液中的CPC相比，CMPC显示出明显改善的可降解性。细胞培养结果表明CMPC具有生物相容性，可以支持细胞附着和增殖。为了研究体内生物相容性和成骨性，将CMPC样品植入兔的骨缺损中。组织学评估表明，将MPC引入CPC可以提高新骨形成的效率。 CMPC在体内与宿主骨骼也表现出良好的生物相容性，生物降解性和骨传导性。获得的结果表明，符合骨组织工程基本要求的CMPC可能比CPC具有显着的临床优势，并且可能具有在整形外科，重建和颌面外科手术中应用的潜力。

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