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首页> 外文期刊>Acta biomaterialia >Dual growth factor releasing multi-functional nanofibers for wound healing
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Dual growth factor releasing multi-functional nanofibers for wound healing

机译：双重生长因子释放多功能纳米纤维，可用于伤口愈合

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The objective of this research is to develop a dual growth factor-releasing nanoparticle-in-nanofiber system for wound healing applications. In order to mimic and promote the natural healing procedure, chitosan and poly(ethylene oxide) were electrospun into nanofibrous meshes as mimics of extracellular matrix. Vascular endothelial growth factor (VEGF) was loaded within nanofibers to promote angiogenesis in the short term. In addition, platelet-derived growth factor-BB (PDGF-BB) encapsulated poly(lactic-co-glycolic acid) nanoparticles were embedded inside nanofibers to generate a sustained release of PDGF-BB for accelerated tissue regeneration and remodeling. In vitro studies revealed that our nanofibrous composites delivered VEGF quickly and PDGF-BB in a relayed manner, supported fibroblast growth and exhibited anti-bacterial activities. A preliminary in vivo study performed on normal full thickness rat skin wound models demonstrated that nanofiberanoparticle scaffolds significantly accelerated the wound healing process by promoting angiogenesis, increasing re-epithelialization and controlling granulation tissue formation. For later stages of healing, evidence also showed quicker collagen deposition and earlier remodeling of the injured site to achieve a faster full regeneration of skin compared to the commercial Hydrofera Blue? wound dressing. These results suggest that our nanoparticle-in-nanofiber system could provide a promising treatment for normal and chronic wound healing.
机译：这项研究的目的是开发用于伤口愈合应用的双重释放因子的纳米纤维纳米颗粒系统。为了模拟和促进自然愈合过程，将壳聚糖和聚环氧乙烷电纺成纳米纤维网，作为细胞外基质的模拟物。血管内皮生长因子（VEGF）被加载到纳米纤维内，以在短期内促进血管生成。另外，将血小板衍生的生长因子-BB（PDGF-BB）封装的聚乳酸-乙醇酸共聚物纳米颗粒嵌入纳米纤维内部，以产生PDGF-BB的持续释放，以加速组织再生和重塑。体外研究表明，我们的纳米纤维复合材料可快速传递VEGF，并以中继方式传递PDGF-BB，支持成纤维细胞生长并表现出抗菌活性。在正常的全厚度大鼠皮肤伤口模型上进行的初步体内研究表明，纳米纤维/纳米颗粒支架通过促进血管生成，增加上皮再形成和控制肉芽组织形成，从而显着加速伤口愈合过程。对于康复的后期阶段，证据还显示，与市售的Hydrofera Blue？相比，胶原蛋白沉积更快，受伤部位更早地重塑，以实现皮肤更快的完全再生。伤口敷料。这些结果表明，我们的纳米纤维纳米系统可以为正常和慢性伤口愈合提供有希望的治疗方法。

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