• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy
【24h】

Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy

机译：基于星形甘露醇核心PLGA-TPGS二嵌段共聚物的多西他赛负载纳米颗粒用于乳腺癌治疗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A star-shaped biodegradable polymer, mannitol-core poly(d,l-lactide-co- glycolide)-d-α-tocopheryl polyethylene glycol 1000 succinate (M-PLGA-TPGS), was synthesized in order to provide a novel nanoformulation for breast cancer chemotherapy. This novel copolymer was prepared by a core-first approach via three stages of chemical reaction, and was characterized by nuclear magnetic resonance, gel permeation chromatography and thermogravimetric analysis. The docetaxel-loaded M-PLGA-TPGS nanoparticles (NPs), prepared by a modified nanoprecipitation method, were observed to be near-spherical shape with narrow size distribution. Confocal laser scanning microscopy showed that the uptake level of M-PLGA-TPGS NPs was higher than that of PLGA NPs and PLGA-TPGS NPs in MCF-7 cells. A significantly higher level of cytotoxicity was achieved with docetaxel-loaded M-PLGA-TPGS NPs than with commercial Taxotere?, docetaxel-loaded PLGA-TPGS and PLGA NPs. Examination of the drug loading and encapsulation efficiency proved that star-shaped M-PLGA-TPGS could carry higher levels of drug than linear polymer. The in vivo experiment showed docetaxel-loaded M-PLGA-TPGS NPs to have the highest anti-tumor efficacy. In conclusion, the star-like M-PLGA-TPGS copolymer shows potential as a promising drug-loaded biomaterial that can be applied in developing novel nanoformulations for breast cancer therapy.
机译：合成了星形生物可降解聚合物，以甘露醇为核心的聚（d，l-丙交酯-乙交酯）-d-α-生育酚聚乙二醇1000琥珀酸酯（M-PLGA-TPGS），为乳腺癌化疗。该新型共聚物是通过先核后化学反应的三个阶段制备的，并通过核磁共振，凝胶渗透色谱和热重分析进行了表征。观察到通过改良的纳米沉淀法制备的多西他赛负载的M-PLGA-TPGS纳米颗粒（NPs）为近球形，尺寸分布较窄。共聚焦激光扫描显微镜显示，MCF-7细胞中M-PLGA-TPGS NP的摄取水平高于PLGA NP和PLGA-TPGS NP的摄取水平。装载多西他赛的M-PLGA-TPGS NPs的细胞毒性水平明显高于商业紫杉醇，装载多西他赛的PLGA-TPGS和PLGA NPs。对药物载量和包封效率的检验证明，星形M-PLGA-TPGS可以比线性聚合物载有更高水平的药物。体内实验表明，装载多西他赛的M-PLGA-TPGS NP具有最高的抗肿瘤功效。总之，星形M-PLGA-TPGS共聚物显示出作为一种有前途的载有药物的生物材料的潜力，该材料可用于开发用于乳腺癌治疗的新型纳米制剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号