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首页> 外文期刊>Acta biomaterialia >Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery
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Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery

机译：锰卟啉共价附着在负载阿霉素的聚乳酸纳米颗粒上，用于潜在的磁共振成像和pH敏感药物递送

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摘要

In this paper, theranostic nanoparticles (MnP-DOX NPs) were fabricated by conjugating Mn-porphyrin onto the surface of doxorubicin (DOX)-loaded poly(lactic acid) (PLA) nanoparticles (DOX NPs) for potential T1 magnetic resonance imaging and pH-sensitive drug delivery. An in vitro drug release study showed that the release rate of DOX from MnP-DOX NPs was slow at neutral pH but accelerated significantly in acidic conditions. It was found that MnP-DOX NPs could be easily internalized by HeLa cells and effectively suppressed the growth of HeLa cells and HT-29 cells due to the accelerated drug release in acidic lysosomal compartments. Magnetic resonance imaging (MRI) scanning analysis demonstrated that MnP-DOX NPs had much higher longitudinal relaxivity in water (r1 value of 27.8 mM-1 s-1 of Mn3+) than Mn-porphyrin (Mn(III)TPPS3NH2; r1 value of 6.70 mM-1 s-1 of Mn3+), behaving as an excellent contrast agent for T1-weighted MRI both in vitro and in vivo. In summary, such a smart and promising nanoplatform integrates multiple capabilities for effective cancer diagnosis and therapy.
机译：本文通过将锰卟啉缀合到载有阿霉素（DOX）的聚乳酸（PLA）纳米颗粒（DOX NPs）的表面上制备了治疗性纳米颗粒（MnP-DOX NPs），用于潜在的T1磁共振成像和pH敏感的药物输送。一项体外药物释放研究表明，MnP-DOX NPs中DOX的释放速率在中性pH下较慢，而在酸性条件下则明显加快。结果发现，由于酸性溶酶体区室中药物的加速释放，MnP-DOX NPs易于被HeLa细胞内化，并有效抑制HeLa细胞和HT-29细胞的生长。磁共振成像（MRI）扫描分析表明，MnP-DOX NPs在水中的纵向弛豫度更高（r3的r1值为27.8 mM-1 s-1）比锰卟啉（Mn（III）TPPS3NH2; r1值为6.70） Mn3 +的mM-1 s-1），在体内外均表现为T1加权MRI的出色造影剂。总而言之，这种智能且有前途的纳米平台集成了多种功能，可以有效地诊断和治疗癌症。

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