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首页> 外文期刊>Acta biomaterialia >Dual delivery of chlorhexidine and platelet-derived growth factor-BB for enhanced wound healing and infection control
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Dual delivery of chlorhexidine and platelet-derived growth factor-BB for enhanced wound healing and infection control

机译：洗必泰和血小板源性生长因子-BB的双重给药可增强伤口愈合和感染控制

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Wound treatment can require molecules that both enhance healing and control infection. As in many biomedical applications, the options for therapeutic molecules may include both hydrophilic and hydrophobic molecules. The goal of this study was to investigate a polymer system for drug delivery that simultaneously delivers platelet-derived growth factor (PDGF)-BB, a hydrophilic protein known to promote wound healing, and chlorhexidine (CHX), a hydrophobic antimicrobial agent for infection treatment. Poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared using different polymer formulations in a double emulsion process. CHX encapsulation efficiency was 19.6 ?? 0.8% and 28.9 ?? 1.5% for PLGA 50:50 and 85:15, respectively. The presence of CHX significantly increased PDGF-BB encapsulation efficiency relative to PDGF-BB alone. Both molecules could be released for up to 50 days and exhibited bioactivity for greater than 3 (PLGA 85:15) or 8 (PLGA 50:50) weeks using in vitro bacteria and cellular assays. An infected wound model was used to evaluate the system in vivo. Wounds treated with the dual delivery system showed decreased levels of infection and increased healing. Vascular analysis of wound tissues also showed higher levels of mature vasculature with the delivery of PDGF-BB. In conclusion, we have evaluated a drug delivery system for simultaneous delivery of hydrophobic and hydrophilic molecules and have shown that this system can improve healing and reduce bacteria levels in an infected wound model. This system could be applied to other therapeutic applications where sustained delivery of hydrophobic and hydrophilic molecules is required.
机译：伤口治疗可能需要既能促进愈合又能控制感染的分子。如在许多生物医学应用中，治疗性分子的选择可以包括亲水性和疏水性分子。这项研究的目的是研究一种用于同时递送血小板衍生生长因子（PDGF）-BB（一种已知可促进伤口愈合的亲水性蛋白质）和氯己定（CHX）（一种用于治疗感染的疏水性抗菌剂）的聚合物给药系统。使用不同的聚合物配方，在双乳液工艺中制备了聚乳酸-乙醇酸共聚物（PLGA）微球。 CHX的封装效率为19.6 ?? 0.8％和28.9 ??对于PLGA 50:50和85:15，分别为1.5％。相对于单独的PDGF-BB，CHX的存在显着提高了PDGF-BB的包封效率。使用体外细菌和细胞测定法，这两种分子最多可释放50天，并显示超过3周（PLGA 85:15）或8周（PLGA 50:50）的生物活性。被感染的伤口模型用于评估体内系统。用双重递送系统治疗的伤口显示出降低的感染水平和增加的愈合。伤口组织的血管分析还显示，随着PDGF-BB的递送，成熟血管的水平更高。总之，我们评估了同时递送疏水性和亲水性分子的药物递送系统，并表明该系统可以改善感染伤口模型中的愈合并降低细菌水平。该系统可用于需要持续输送疏水和亲水分子的其他治疗应用。

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