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首页> 外文期刊>Acta biomaterialia >Bioactive glass-derived hydroxyapatite-coating promotes granulation tissue growth in subcutaneous cellulose implants in rats.
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Bioactive glass-derived hydroxyapatite-coating promotes granulation tissue growth in subcutaneous cellulose implants in rats.

机译：生物活性玻璃衍生的羟基磷灰石涂层促进大鼠皮下纤维素植入物中肉芽组织的生长。

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Granulation tissue was induced in hydroxyapatite-coated cellulose sponges with subcutaneous implantation in rats. A massive inflammatory reaction with an intense foreign body reaction and an increased invasion of fibrovascular tissue was observed by days 1-3 post-operation, whereas tissue growth into the uncoated control implants was much slower and took place mainly on their surfaces. The foreign body reaction in apatite-coated sponges declined after post-operative day 14, and no obvious differences were seen between the two cellulose sponges from 1 month up to 1 year after implantation. The apatite-coated implants attracted macrophages and fibroblasts, and favored angiogenesis. The excessive connective tissue formation was histologically normal, synthesized the major extracellular matrix molecules in a normal ratio and did not seem to disturb the animals in any way. These results warrant further investigations on clinical applicability of hydroxyapatite-coated cellulose sponges, when fast proliferation of connective tissue is desirable.
机译：在大鼠皮下植入羟基磷灰石包裹的纤维素海绵中诱导肉芽组织。术后1-3天观察到大量炎症反应，伴有强烈的异物反应，并增加了纤维血管组织的侵袭，而未涂覆的对照植入物的组织生长要慢得多，并且主要发生在其表面。术后第14天后，磷灰石涂层海绵的异物反应下降，从植入后1个月到1年，两种纤维素海绵之间没有发现明显差异。磷灰石涂层的植入物吸引了巨噬细胞和成纤维细胞，并促进了血管生成。过度的结缔组织形成在组织学上是正常的，以正常比例合成了主要的细胞外基质分子，似乎没有以任何方式干扰动物。当需要结缔组织的快速增殖时，这些结果需要对羟基磷灰石涂层的纤维素海绵的临床适用性进行进一步的研究。

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