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首页> 外文期刊>Acta biomaterialia >Fibrous poly(chitosan-g-dl-lactic acid) scaffolds prepared via electro-wet-spinning.
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Fibrous poly(chitosan-g-dl-lactic acid) scaffolds prepared via electro-wet-spinning.

机译：通过电湿纺法制备的纤维状聚（壳聚糖-g-dl-乳酸）支架。

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dl-Lactic acid was grafted onto chitosan to produce poly(chitosan-g-dl-lactic acid)(PCLA) copolymers. These PCLAs were then spun into submicron and/or nanofibers to fabricate scaffolds using an electro-wet-spinning technique. The diameter of fibers in different scaffolds could vary from about 100nm to around 3mum. The scaffolds exhibited various pore sizes ranging from about 1mum to less than 30mum and different porosities up to 80%. Two main processing parameters, that is, the concentration of PCLA solutions and the composition proportions of coagulation solutions, were optimized for obtaining desired scaffolds with well-controlled structures. The tensile properties of the scaffolds in both dry and hydrated states were examined. Significantly improved tensile strength and modulus for these fibrous scaffolds in their hydrated state were observed. The data collected from in vitro rabbit-fibroblast/scaffold culture showed that there were no substantial differences in the viability, density and distribution of cultured fibroblasts between PCLA scaffolds and pure chitosan scaffolds.
机译：将dl-乳酸接枝到壳聚糖上以生产聚（壳聚糖-g-dl-乳酸）（PCLA）共聚物。然后使用电湿纺技术将这些PCLA纺成亚微米和/或纳米纤维，以制造支架。不同支架中的纤维直径可以在约100nm至约3μm之间变化。支架表现出从约1μm到小于30μm的各种孔尺寸和高达80％的不同孔隙率。优化了两个主要的加工参数，即PCLA溶液的浓度和混凝溶液的组成比例，以获得具有良好控制结构的所需支架。检查了支架在干燥和水合状态下的拉伸性能。观察到这些纤维状支架在水合状态下的抗张强度和模量显着提高。从体外兔成纤维细胞/支架培养物中收集的数据表明，在PCLA支架和纯壳聚糖支架之间，培养的成纤维细胞的生存力，密度和分布没有实质性差异。

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