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首页> 外文期刊>RSC Advances >Monoclonal antibody-tagged polyethylenimine (PEI)/poly(lactide) (PLA) nanoparticles for the enhanced delivery of doxorubicin in HER-positive breast cancers
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Monoclonal antibody-tagged polyethylenimine (PEI)/poly(lactide) (PLA) nanoparticles for the enhanced delivery of doxorubicin in HER-positive breast cancers

机译：单克隆抗体标记的聚乙烯亚胺（PEI）/聚（丙交酯）（PLA）纳米颗粒，用于在她阳性乳腺癌中增强多柔比星的递送

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摘要

Poor therapeutic response and adverse side effects of chemotherapeutic agents are the major obstacles for effective chemotherapy against breast cancers. In this study, we reported a successful application of an Herceptin-tagged polyethylenimine (PEI) and poly (lactide) PEI/PLA nanoparticle system (hPPD) to deliver the chemotherapeutic drug doxorubicin (DOX) to HER2-positive breast cancer cells for improved efficacy of chemotherapy. The prepared nanoparticles were nanosized and exhibited a typical controlled drug release pattern suggesting its suitability for biomedical applications. The presence of Herceptin on the nanoparticle surface enhanced the accumulation of carrier on the cellular cytoplasm as is evident from the CLSM image. Our data showed that hPPD could significantly inhibit the proliferation of breast cancer cells compared to that with free DOX. Furthermore, Herceptin-based nanocarrier-mediated delivery of DOX could not only enhance the therapeutic outcome of using the anticancer drug, but also reduced the side effects of DOX in an effective manner in a xenograft tumor model. Overall, the Herceptin-tagged nanosystem demonstrates great potential as a novel therapeutic strategy in the anticancer treatment of HER2-positive breast cancers.
机译：化学治疗剂的治疗反应差和不良副作用是对乳腺癌有效化疗的主要障碍。在这项研究中，我们报告了将赫赛汀标记的聚乙烯亚胺（PEI）和聚（丙交酯）PEI / PLA纳米粒子系统（HPPD）的成功应用，以将化学治疗药物DOOXORUBICIN（DOX）输送到HER2阳性乳腺癌细胞中，以提高疗效化疗。制备的纳米颗粒纳米颗粒，表现出典型的受控药物释放模式，表明其适用于生物医学应用。纳米粒子表面上的赫赛汀的存在增强了载体对细胞细胞质上的积累，因为从CLSM图像中明显明显。我们的数据显示，与免费DOX相比，HPPD可以显着抑制乳腺癌细胞的增殖。此外，赫赛汀的纳米载体介导的DOX递送不仅可以增强使用抗癌药物的治疗结果，而且还可以在异种移植肿瘤模型中以有效方式降低DOX的副作用。总的来说，赫赛汀标记的纳米系统表明，作为抗癌治疗抗癌治疗的新疗效潜力很大。

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  • 来源
    《RSC Advances》 |2016年第83期|共8页
  • 作者

    Cui Ning; Zhu Su-Hua;

  • 作者单位

    First Peoples Hosp Henan Dept Gen Surg Shangqiu 476000 Peoples R China;

    First Peoples Hosp Henan Shangqiu Dept Tradit Chinese Med Surg 292 Kaixuan Rd Shangqiu 476000 Henan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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