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Interactions governing the entrapment of anticancer drugs by low-molecular-weight hydrogelator for drug delivery applications

机译：用低分子量水凝胶试剂治疗抗癌药物的相互作用

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摘要

We present the effect of size, charge, and hydrophobicity of anticancer drugs on their drug encapsulation efficacy in an L-alanine-based small-molecule hydrogelator. Entrapment of various anticancer drugs in a hydrogel was depicted and correlated towards interactions between gelator and drug molecules. Hydrogel showed the highest entrapment for 5-fluorouracil, which was as high as similar to 1.2 mg mL(-1) in 1.5% (w/v) hydrogel; however, with small polar anticancer drugs such as cisplatin and carboplatin, poor encapsulation was observed. Hydrogel was also able to entrap and retain hydrophobic drugs, such as docetaxel and tamoxifen, with a high drug-loading efficiency. The hydrogel-entrapped drugs were then characterized by rheology and SEM studies to understand the effect of the drugs on hydrogel assembly. Drug release and anticancer activity studies showed slow and sustained release of drugs from hydrogels, making them suitable for exploring with regard to future cancer therapeutic applications.
机译：我们展示了抗癌药物对基于L-丙氨酸基小分子水凝胶中的药物包封效果的尺寸，电荷和疏水性的影响。描绘了水凝胶中各种抗癌药物的捕获并与胶凝胶和药物分子之间的相互作用相关。水凝胶显示出5-氟尿嘧啶的最高夹带，其高于1.5％（w / v）水凝胶的1.2mg ml（-1）;然而，对于小极性抗癌药，例如顺铂和卡铂，观察到差的封装。水凝胶还能够捕获并保留疏水药，例如多西紫杉醇和三莫昔芬，具有高药物负载效率。然后通过流变和SEM研究表征水凝胶簇的药物，以了解药物对水凝胶组件的影响。药物释放和抗癌活性研究表明，来自水凝胶的药物缓慢和持续释放，使其适合于探索未来的癌症治疗应用。

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  • 来源
    《RSC Advances》 |2016年第24期|共7页
  • 作者

    Gupta Siddhi; Singh Manish; Reddy Amarendar M.; Yavvari Prabhu S.; Srivastava Aasheesh; Bajaj Avinash;

  • 作者单位

    Indian Inst Sci Educ &

    Res Bhopal Dept Chem Bhopal 462066 India;

    Reg Ctr Biotechnol Lab Nanotechnol &

    Chem Biol Faridabad Haryana India;

    Indian Inst Sci Educ &

    Res Bhopal Dept Chem Bhopal 462066 India;

    Indian Inst Sci Educ &

    Res Bhopal Dept Chem Bhopal 462066 India;

    Indian Inst Sci Educ &

    Res Bhopal Dept Chem Bhopal 462066 India;

    Reg Ctr Biotechnol Lab Nanotechnol &

    Chem Biol Faridabad Haryana India;

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  • 正文语种 eng
  • 中图分类 化学;
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