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首页> 外文期刊>RSC Advances >Chondroitin sulfate-functionalized polyamidoamine-mediated miR-34a delivery for inhibiting the proliferation and migration of pancreatic cancer
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Chondroitin sulfate-functionalized polyamidoamine-mediated miR-34a delivery for inhibiting the proliferation and migration of pancreatic cancer

机译：硫酸软骨素官能化聚酰胺介导的miR-34A递送，用于抑制胰腺癌的增殖和迁移

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摘要

Herein, chondroitin sulfate-functionalized polyamidoamine (CS-PAMAM) was employed as a carrier in miR-34a delivery, and the inhibition of cell proliferation and migration of pancreatic cancer was systematically evaluated, using human pancreatic carcinoma cell line MiaPaCa-2 as a model. Through confocal laser scanning microscopy, an efficient cellular uptake of CS-PAMAM/miR-34a nanoparticles has been demonstrated to be executed in a CD44-dependent manner. After the successful delivery of miR-34a, the cell proliferation could be obviously inhibited due to the activation of cell apoptosis and cell cycle arrest. Meanwhile, CS-PAMAM-mediated miR-34a delivery could realize the suppression of cell migration elucidated by wound healing and transwell migration assays. Thus, the derivative CS-PAMAM could potentially be used as an effective carrier for miR-34a delivery to achieve the tumor gene therapy.
机译：在此，硫酸软骨素官能化聚酰胺（CS-PAMAM）用作MIR-34A递送中的载体，系统地评估了人类胰腺癌细胞系MIAPACA-2作为模型，抑制细胞增殖和胰腺癌的迁移 。 通过共聚焦激光扫描显微镜，已经证明了CS-PAMAM / miR-34a纳米颗粒的有效细胞摄取以以CD44依赖性方式执行。 在成功递送miR-34a之后，由于细胞凋亡和细胞循环骤停性，细胞增殖可能明显抑制。 同时，CS-PAMAM介导的miR-34a递送可以实现伤口愈合和转发迁移测定阐明的细胞迁移的抑制。 因此，衍生物CS-PAMAM可能被用作MIR-34A递送的有效载体以实现肿瘤基因治疗。

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  • 来源
    《RSC Advances》 |2016年第75期|共7页
  • 作者

    Duan Yan; Xing Zhen; Yang Jiebing; Wang Yudi; Chen Jiawen; Zhang Yan; Shi Wei; Li Quanshun;

  • 作者单位

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

    Jilin Univ Sch Life Sci Minist Educ Key Lab Mol Enzymol &

    Engn Changchun 130012 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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