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首页> 外文期刊>RSC Advances >Ethylene brassylate-co-delta-hexalactone biobased polymers for application in the medical field: synthesis, characterization and cell culture studies
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Ethylene brassylate-co-delta-hexalactone biobased polymers for application in the medical field: synthesis, characterization and cell culture studies

机译：乙烯碳酸亚胺 - 共δ-六甲基酮生物化聚合物用于医疗领域的应用：合成，表征和细胞培养研究

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摘要

Copolymers based on ethylene brassylate (EB) and delta-hexalactone (delta-HL), two monomers obtained from renewable sources, were synthesized with triphenyl bismuth by ring-opening polymerization. The poly(EB-co-delta-HL), with EB molar contents ranging from 49 to 90%, presented a slight deviation from the random distribution of sequences (R > 0.71) while WAXS measurements proved that only the EB blocks were able to crystallize (with crystallinity degrees of similar to 23-39%). The low T-g(s) (<-27 degrees C), their reduced crystallization capability and melting temperatures from 50 to 65 degrees C make these thermoplastic elastomers (of good thermal stability) very easy to process. Likewise, their thermal properties led to mechanical behaviour with improved flexibility in comparison to poly(epsilon-caprolactone) or poly(omega-pentadecalactone) (elastic modulus between 57-274 MPa with high elongation at break values) at both 21 degrees C and 37 degrees C. On the other hand, the incorporation of delta-HL in addition to increase the amorphous character, brought a more disordered chain microstructure distribution, resulting in higher degradation rates in the range of 0.0028-0.0041 per day. Finally, metabolic activity and cell morphology studies using human dermal fibroblasts (HDFs) demonstrated that these materials are not cytotoxic and provide a valid substrate for cells to attach and proliferate, meaning that they are suitable for use in the biomedical field.
机译：基于乙基碳酸丁酯（EB）和δ-六甲烷（DELTA-HL）的共聚物，通过开环聚合用三苯基铋合成两种单体。具有49〜90％的EB摩尔含量，呈现出与序列的随机分布（R> 0.71）的略微偏差，而蜡测量证明只有EB块能够结晶（结晶度与23-39％相似的结晶度）。低T-g（S）（<-27℃），其降低的结晶能力和50至65℃的熔化温度使这些热塑性弹性体（良好的热稳定性）非常易于加工。同样，它们的热性能导致机械行为，与聚（ε-己内酯）或聚（Omega-五甲烷酮）（在21℃和37之间的57-274MPa的弹性模量之间的弹性模量之间的弹性模量）（在57-274MPa的高伸长率之间）另一方面C.另一方面，除了增加非晶特性之外的δ-HL掺入更混乱的链微观结构分布，导致每天0.0028-0.0041的降解率较高。最后，使用人的皮肤成纤维细胞（HDFS）的代谢活性和细胞形态学研究表明，这些材料不是细胞毒性并为细胞提供有效的基材以连接和增殖，这意味着它们适用于生物医学领域。

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  • 来源
    《RSC Advances》 |2016年第26期|共16页
  • 作者

    Fernandez Jorge; Larranaga Aitor; Etxeberria Agustin; Sarasua Jose-Ramon;

  • 作者单位

    Univ Basque Country UPV EHU POLYMAT Sch Engn Dept Min Met Engn &

    Mat Sci Alameda Urquijo S-N Bilbao 48013 Spain;

    Univ Basque Country UPV EHU POLYMAT Sch Engn Dept Min Met Engn &

    Mat Sci Alameda Urquijo S-N Bilbao 48013 Spain;

    Univ Basque Country UPV EHU POLYMAT Dept Polymer Sci &

    Technol M de Lardizabal 3 Donostia San Sebastian 20018 Spain;

    Univ Basque Country UPV EHU POLYMAT Sch Engn Dept Min Met Engn &

    Mat Sci Alameda Urquijo S-N Bilbao 48013 Spain;

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  • 正文语种 eng
  • 中图分类 化学;
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