Penicillanthone and penicillidic acids A-C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105

Daengrot Charuwan; Rukachaisirikul Vatcharin; Tadpetch Kwanruthai; Phongpaichit Souwalak; Bowornwiriyapan Kawitsara; Sakayaroj Jariya; Shen Xu

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Penicillanthone and penicillidic acids A-C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105

机译：Penicillanthone和青霉素酸A-C来自土壤衍生的真菌青霉素aculeatum psu-rspg105

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A new xanthone (penicillanthone, 1) and three new diphenyl ether derivatives (penicillidic acids A-C, 2-4) together with 14 known compounds (5-18) were isolated from the soil-derived fungus Penicillium aculeatum PSU-RSPG105. The structures were elucidated by spectroscopic analyses. The absolute configuration of compound 1 was determined using the Snatzke's method whereas those of compounds 2-4 was established by comparison of their optical rotations with those of structurally related compounds. Compound 5 exhibited mild antimycobacterial activity against Mycobacterium tuberculosis with an MIC value of 25 mu g mL (1) and was noncytotoxic to noncancerous Vero cells. In addition, altenusin (12) displayed moderate antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 32 mu g mL(-1) and mild activity towards Vero cells with an IC50 value of 19.46 mu M.

机译：与14种已知化合物（5-18）一起分离出一种新的Xhanthone（Penicillanthone，1）和三种新的二苯基醚衍生物（三苯基酸A-C，2-4），从土壤衍生的真菌青霉酰琥珀酸盐PSU-RSPG105中分离。通过光谱分析阐明了结构。使用Snatzke的方法测定化合物1的绝对构型，而通过将它们的光学旋转与结构相关化合物的光学旋转比较来确定化合物2-4的绝对构型。化合物5表现出对结核分枝杆菌的温和抗致细菌活性，MIC值为25μg（1），并对非癌症的vero细胞是非胞毒性毒性的。此外，Altenusin（12）展示针对耐甲氧西林耐金葡萄球菌的中度抗菌活性，MIC值为32μgml（-1）和轻度活性，朝向Vero细胞，IC50值为19.46亩。

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《RSC Advances》 |2016年第46期|共10页
作者
Daengrot Charuwan; Rukachaisirikul Vatcharin; Tadpetch Kwanruthai; Phongpaichit Souwalak; Bowornwiriyapan Kawitsara; Sakayaroj Jariya; Shen Xu;
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作者单位

Prince Songkla Univ Dept Chem Hat Yai 90112 Thailand;

Prince Songkla Univ Dept Chem Hat Yai 90112 Thailand;

Prince Songkla Univ Dept Chem Hat Yai 90112 Thailand;

Prince Songkla Univ Nat Prod Res Ctr Excellence Hat Yai 90112 Thailand;

Prince Songkla Univ Nat Prod Res Ctr Excellence Hat Yai 90112 Thailand;

Natl Ctr Genet Engn &

Biotechnol BIOTEC Thailand Sci Pk Khlong Luang 12120 Pathum Thani Thailand;

Chinese Acad Sci Shanghai Inst Mat Med Shanghai 201203 Peoples R China;

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正文语种 eng
中图分类化学;
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1. Penicillanthone and penicillidic acids A-C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105 [J] . Daengrot Charuwan, Rukachaisirikul Vatcharin, Tadpetch Kwanruthai, RSC Advances . 2016,第46期

机译：Penicillanthone和青霉素酸A-C来自土壤衍生的真菌青霉素aculeatum psu-rspg105
2. Penicillanthone and penicillidic acids A–C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105 [J] . Charuwan Daengrot, Vatcharin Rukachaisirikul, Kwanruthai Tadpetch, RSC Advances . 2016,第46期

机译：Penicillanthone和青霉素酸A-C来自土壤衍生的真菌青霉素aculeatum psu-rspg105
3. Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07 [J] . ChenZ., ZhengZ., HuangH., Bioorganic and Medicinal Chemistry Letters . 2012,第9期

机译：青霉酸A-C，三种新的麦考酚酸衍生物和来自海洋真菌Penicillium sp。的免疫抑制活性。 SOF07
4. ADSORPTION OF NUCLEIC ACID CONSTITUENTS ADENINE AND ADENOSINE ON AN IRON(III)-LOADED SOIL-DERIVED HUMIC ACID [C] . Elham A.Ghabbour, Kathleen Collins, Jong-Bum T.Park International Meeting of IHSS . 2004

机译：在铁（III）载荷的土壤衍生腐殖酸上的核酸成分腺苷和腺苷的吸附
5. Purification and characterization of an aromatic L-amino acid decarboxylase from Penicillium raistrickii isolate H10BA2, the transformation of this fungus, and investigation of taxa-4(5),11(12)-diene synthase. [D] . Niedens, Bret Reger. 1997

机译：纯化和表征从雷氏青霉分离株H10BA2的芳香族L-氨基酸脱羧酶，这种真菌的转化，和分类单元4（5），11（12）-二烯合酶的研究。
6. Response Surface Methodology Optimization of an Acidic Protease Produced by Penicillium bilaiae Isolate TDPEF30 a Newly Recovered Endophytic Fungus from Healthy Roots of Date Palm Trees (Phoenix dactylifera L.) [O] . Fedia Ben Mefteh, Fakher Frikha, Amal Daoud, 2019

机译：响应面方法学优化了从青枣（Phoenix dactylifera L.）的健康根中新分离出的内生真菌Bilaiillium bilaiae分离物TDPEF30产生的酸性蛋白酶。
7. Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum) [O] . Suthatip Ngokpol, Wittaya Suwakulsiri, Sanya Sureram, 2015

机译：来自真菌Talaromyces minioluteus（penicillium minioluteum）的海洋分离物的Drimane sesquiterpene-共轭氨基酸

Penicillanthone and penicillidic acids A-C from the soil-derived fungus Penicillium aculeatum PSU-RSPG105

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