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Fe3O4@Pt/MWCNT/carbon paste electrode for determination of a doxorubicin anticancer drug in a human urine sample

机译:Fe3O4 @ Pt / MWCNT /碳浆电极用于测定人类尿液样品中的多柔比蛋白抗癌药物

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In this study, a Fe3O4@Pt nanoparticle and multi-walled carbon nanotube (MWCNT) modified carbon paste electrode was used as a fast and sensitive tool for the electrochemical determination of doxorubicin (DOX). The electrochemical oxidation of DOX was investigated at Fe3O4@Pt/MWCNT/CPE using the differential pulse voltammetry method. The developed electrode exhibited excellent electrochemical activity towards the electrochemical oxidation of the investigated anticancer drug. Under the optimized experimental conditions, a linear calibration curve in the range of 0.05 to 70.0 mmol L-1 with two different slopes and a detection limit of 1 nmol L-1 was obtained. Finally, the method was successfully employed for the voltammetric determination of DOX in a urine sample at trace levels with good recoveries.
机译:在该研究中,Fe3O4 @ Pt纳米颗粒和多壁碳纳米管(MWCNT)改性碳浆料用作电化学测定的多柔比蛋白(DOX)的快速和敏感的工具。 使用差分脉冲伏安法法在Fe3O4 @ Pt / MWCNT / CPE下研究DOX的电化学氧化。 开发电极表现出优异的电化学活性朝向研究的抗癌药的电化学氧化。 在优化的实验条件下,获得具有两个不同斜率的0.05至70.0mmol L-1的线性校准曲线和1nmol L-1的检测限。 最后,该方法已成功用于在痕量水平下尿液样品中DOX的伏安测定,具有良好的回收率。

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