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首页> 外文期刊>RSC Advances >Construction of a bone-like surface layer on hydroxyl-modified carbon/carbon composite implants via biomimetic mineralization and in vivo tests
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Construction of a bone-like surface layer on hydroxyl-modified carbon/carbon composite implants via biomimetic mineralization and in vivo tests

机译：通过仿生矿化和体内试验构建羟基改性碳/碳复合材料植入物上的骨状表面层

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摘要

Carbon/carbon composites, solely composed of pure carbon, are typical fiber fabric reinforced porous composites. They have been widely studied due to their excellent bio-inert performance and mechanical properties. However, their applications are restricted by two problems, i.e., easy dissociation of surface carbon particles and poor wettability of common bioactive coatings on their surface. To overcome these problems, we have adopted a biomimetic mineralization method, where Mg-doped hydroxyapatite particles were successfully prepared on hydroxyl-modified C/C surfaces, prepared via HNO3 oxidation. In this way, the original porous morphology of C/C, which is conducive to cell proliferation, is well-preserved. In the meanwhile, the introduction of electrochemical methods sped up the process of biomineralization and facilitated the construction of bone-like surface layers. In vivo tests revealed that 90 days after implantation for bone defect repair, the resulting C/C displayed unprecedented surface chemical stability and biocompatibility.
机译：碳/碳复合材料仅由纯碳组成，是典型的纤维织物增强多孔复合材料。由于它们出色的生物惰性性能和机械性能，它们已被广泛研究。然而，它们的应用受到两个问题的限制，即表面碳颗粒的易于解离以及它们表面上常见的生物活性涂层的润湿性差。为了克服这些问题，我们采用了一种仿生矿化方法，其中通过HNO3氧化制备的羟基改性的C / C表面上成功制备了Mg掺杂的羟基磷灰石颗粒。通过这种方式，有利于细胞增殖的C / C的原始多孔形态是完全保存的。同时，电化学方法引入加快了生物矿化的过程，促进了骨状表面层的结构。体内试验显示，植入骨缺损修复后90天，所得C / C显示出前所未有的表面化学稳定性和生物相容性。

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  • 来源
    《RSC Advances》 |2016年第11期|共9页
  • 作者

    Cao Ning; Yang Zhenguo; Yang Bai; Wang Wenbo; Boukherroub Rabah; Li Musen;

  • 作者单位

    China Univ Petr Coll Mech &

    Elect Engn Qingdao 266580 Peoples R China;

    Shandong Univ Chinese Tradit Med Affiliated Hosp 2 Jinan 250001 Peoples R China;

    China Univ Petr Coll Mech &

    Elect Engn Qingdao 266580 Peoples R China;

    Shandong Univ Chinese Tradit Med Affiliated Hosp 2 Jinan 250001 Peoples R China;

    Univ Lille 1 Inst Elect Microelect &

    Nanotechnol UMR CNRS8520 Ave Poincare BP60069 F-59652 Villeneuve Dascq France;

    Shandong Univ Minist Educ Key Lab Liquid Solid Struct Evolut &

    Proc Mat Jinan 250061 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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