• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Antioxidant properties of Artemisia herba-alba and Eucalyptus camaldulensis essentials oils on malathion-induced reproductive damage in rat
【24h】

Antioxidant properties of Artemisia herba-alba and Eucalyptus camaldulensis essentials oils on malathion-induced reproductive damage in rat

机译：蒿属植物的抗氧化特性和桉树玉米醛植物对大鼠的恶性诱导的生殖损伤的精油

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Malathion (M) is an organophosphorus pesticide of utmost concern because of its adverse effects on non-targeted organisms. It is well-known for its anti-acetylcholinesterase activity and its negative effects on the liver, pancreas and the immune, hematological and reproductive systems. Natural antioxidants including phenolics, essential oils and vitamins, among others, might have protective effects on the toxicity of malathion. The intent of this study was to examine whether the treatment with Artemisia herba-alba (AhaEO) and Eucalyptus camaldulensis (EcEO) essential oils may be useful to overcome the deleterious effects of malathion administration on reproductive function in male rats. Depending on what group they were in, the following dosages were administered to rats via oral gavage for 21 days: only malathion at a dose of 200 mg kg(-1) b.w.; malathion (200 mg kg(-1) b.w.) following treatment with either AhaEO or EcEO (50 mg kg(-1) b.w.); only AhaEO or EcEO. The results indicate that malathion affects the male reproductive system by the reduction of epididymal sperm count, motility and viability, and by increasing abnormal sperm morphology. These effects were tightly associated with oxidative stress, as revealed by the significant increase in lipid peroxidation (MDA) and hydrogen peroxide (H2O2), and the decrease in thiol groups (SH) and antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the testis and epididymis of M-treated rats. Essentials oils of AhaEO and EcEO prevented testicular and epididymis oxidative damage, as evidenced by reduced MDA and H2O2 levels, and improved total sperm motility, viability and morphology in rat spermatozoa. Our study shows that AhaEO and EcEO can offer protection against malathion-induced reproductive toxicity via their potent antioxidant activity, and may become a potential treatment for male infertility associated with malathion exposure.
机译：Malathion（M）是一种极其关注的有机磷农药，因为它对非靶向生物的不利影响。它以其抗乙酰胆碱酯酶活性及其对肝脏，胰腺和免疫，血液和生殖系统的负面影响而闻名。包括酚类，精油和维生素在内的天然抗氧化剂可能对malathion的毒性产生保护作用。本研究的目的是检查用蒿甲虫（Ahaeo）和桉树植物（ECEO）和eucalyptus camaldulensis（Eceo）精油的治疗可能有助于克服马拉硫灭绝对雄性大鼠生殖功能的有害影响。取决于它们所处的群体，通过口服饲养给大鼠进行以下剂量21天：只有200mg kg（-1）B.W的剂量才能脱脂。在用Ahaeo或Eceo治疗后（50mg kg（-1）b.W.）处理后，马拉硫磷（200mg kg（-1）b.w.）;只有Ahaeo或Eceo。结果表明，马拉硫磷通过减少附睾精子计数，运动和活力来影响雄性生殖系统，以及增加异常精子形态。这些效果与氧化应激紧密相关，如脂质过氧化（MDA）和过氧化氢（H2O2）的显着增加，以及硫醇基（SH）和抗氧化酶如超氧化物歧化酶（SOD），过氧化氢酶（猫）和谷胱甘肽过氧化物酶（GPX）在睾丸和M治疗大鼠的耻骨上。 Eshaeo和Eceo的精油预防睾丸和附睾氧化损伤，如减少的MDA和H2O2水平证明，并改善了大鼠精子中的总精子运动，活力和形态。我们的研究表明，Ahaeo和Eceo可以通过其有效的抗氧化活性来提供对恶性生殖毒性的保护，并且可能成为与畸形暴露相关的男性不孕症的潜在治疗方法。

著录项

  • 来源
    《RSC Advances》 |2016年第112期|共13页
  • 作者

    Selmi Slimen; Rtibi Kais; Grami Dhekra; Hajri Azhar; Hosni Karim; Marzouki Lamjed; Sebai Hichem;

  • 作者单位

    Inst Biotechnol Beja Dept Biotechnol Lab Physiol Anim Beja Tunisia;

    Inst Biotechnol Beja Dept Biotechnol Lab Physiol Anim Beja Tunisia;

    Inst Biotechnol Beja Dept Biotechnol Lab Physiol Anim Beja Tunisia;

    Inst Biotechnol Beja Dept Biotechnol Lab Physiol Anim Beja Tunisia;

    Biotechpole Sidi Thabet INRAP Lab Subst Nat Sidi Thabet 2020 Tunisia;

    Inst Biotechnol Beja Dept Biotechnol Lab Physiol Anim Beja Tunisia;

    Inst Biotechnol Beja Dept Biotechnol Lab Physiol Anim Beja Tunisia;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号