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首页> 外文期刊>RSC Advances >Gold nanorods vs. gold nanoparticles: application in electrochemical sensing of cytosine beta-D-arabinoside using metal ion mediated molecularly imprinted polymer
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Gold nanorods vs. gold nanoparticles: application in electrochemical sensing of cytosine beta-D-arabinoside using metal ion mediated molecularly imprinted polymer

机译：金纳米棒与金纳米颗粒：使用金属离子介导的分子印迹聚合物在胞嘧啶β-D-阿拉伯核苷的电化学传感中的应用

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The determination of an anticancer drug (cytosine arabinoside, Ara-C) in body fluids is very important due to its pharmaceutical and clinical significance. This drug is widely used for the treatment of cancer patients suffering from acute myeloid leukemia. In this study, a typical surface imprinting approach was adopted for the immobilization of imprinted nano film on a pencil graphite electrode decorated with gold nanorods/gold nano particles. For this, gold nanorods were attached first onto the electrode surface followed by their modification with a pre-polymer mixture. Herein, monomeric molecules (N-methacryloyl-L-cysteine) were coated via Au-S links on an electrode surface that had undergone metal ion mediated molecularly imprinted polymerization, in the presence of a template (Ara-C), crosslinker (ethylene glycol dimethacrylate) and initiator [2,2'-azobis(isobutyronitrile)]. Similar modification was carried out on a gold nanoparticles immobilized electrode for comparison, in terms of differential pulse anodic stripping voltammetric transduction and measurement sensitivity. An extended imprinting polymer (template-free) coating on the longitudinal surface of the gold nanorods was found to reveal higher electrode kinetics. This produced a better signal with enhanced detection sensitivity (k = 1.36 x 10(-2), linearity range = 1.00-126.71 ng mL(-1), limit of detection = 0.19 ng mL(-1)) of the drug than those (k = 1.75 x 10(-3), linearity range = 3.00-107.21 ng mL(-1), limit of detection = 0.75 ng mL(-1)) realized with a gold nanoparticles decorated imprinted polymer layer compressed in spherical curved space. Consequently, the proposed gold nanorods-based imprinted sensor is adjudged to be better in helping to monitor a dose-dependent antiproliferative effect of a drug and its supplementation in chemotherapy.
机译：在体液抗癌药物（阿糖胞苷，阿糖胞苷）的确定为它的药物和临床意义非常重要的因。这种药物被广泛用于从急性髓系白血病患癌症患者的治疗。在这项研究中，典型的表面压印方法被用于压印纳米膜的上的铅笔石墨电极装饰有金纳米棒/金纳米颗粒的固定化采用。对于这一点，金纳米棒首先附着在电极表面，随后可以通过与预聚合物混合物改性。这里，单体分子（N-甲基丙烯酰基-L-半胱氨酸）经由已经历金属离子介导的分子印记的聚合，在模板（ARA-C）的存在下，交联剂（乙二醇在电极表面上的Au-S链接涂覆二甲基丙烯酸酯）和引发剂[2,2'-偶氮二（异丁腈）]。类似修饰物上固定化电极用于比较的金纳米颗粒进行，在剥离伏安转导和测量灵敏度微分脉冲阳极的条款。扩展印迹聚合物（无模板）的金纳米棒的纵向表面涂敷发现揭示了更高电极动力学。这产生具有增强的检测灵敏度（K = 1.36×10（-2），线性范围= 1.00-126.71纳克毫升（-1），检测限= 0.19纳克毫升（-1））的药物比那些更好的信号（K = 1.75×10（-3），线性范围= 3.00-107.21纳克毫升（-1），检测限= 0.75纳克毫升（-1）），在球形弯曲空间压缩的金纳米颗粒的装饰印刷的聚合物层来实现。因此，所述基于纳米棒提出金印迹传感器被判更好在帮助监测药物的剂量依赖的抗增殖作用及其在化疗补充。

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  • 来源
    《RSC Advances》 |2016年第84期|共13页
  • 作者

    Prasad Bhim Bali; Singh Ragini; Kumar Anil;

  • 作者单位

    Banaras Hindu Univ Analyt Div Dept Chem Fac Sci Varanasi 221005 Uttar Pradesh India;

    Banaras Hindu Univ Analyt Div Dept Chem Fac Sci Varanasi 221005 Uttar Pradesh India;

    Banaras Hindu Univ Analyt Div Dept Chem Fac Sci Varanasi 221005 Uttar Pradesh India;

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  • 正文语种 eng
  • 中图分类 化学;
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