Measurement of H-1 NMR relaxation times in complex organic chemical systems: application of PSYCHE

Kakita Veera Mohana Rao; Shukla Vaibhav Kumar; Bopardikar Mandar; Bhattacharya Tannistha; Hosur Ramakrishna V.

首页> 外文期刊>RSC Advances >Measurement of H-1 NMR relaxation times in complex organic chemical systems: application of PSYCHE

【24h】

Measurement of H-1 NMR relaxation times in complex organic chemical systems: application of PSYCHE

机译：复合有机化学体系中H-1 NMR弛豫时间的测量：心灵应用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Relaxation times provide a wealth of information on intramolecular dynamics and intermolecular interactions. However, in complex molecular systems with extensive peak overlaps in NMR spectra, relaxation time measurements are severely hampered due to difficulties in quantitation of peak intensities for individual protons. Here, we incorporate PSYCHE homodecoupling in inversion recovery and CPMG NMR experiments to significantly enhance spectral resolution, thereby enabling unambiguous measurement of relaxation times, T-1 and T-2, in two complex systems. This includes a specific application to study drug-protein interactions.

机译：放松时间提供有关分子内动态和分子间相互作用的丰富信息。然而，在NMR光谱中具有广泛峰值重叠的复杂分子系统中，由于各种质子的峰强度定量困难，松弛时间测量严重阻碍。在这里，我们将心理同源耦合在反转恢复和CPMG NMR实验中，以显着提高光谱分辨率，从而使弛豫时间，T-1和T-2中的明确测量在两个复杂的系统中。这包括研究药物 - 蛋白质相互作用的特定应用。

著录项

来源
《RSC Advances》 |2016年第102期|共5页
作者
Kakita Veera Mohana Rao; Shukla Vaibhav Kumar; Bopardikar Mandar; Bhattacharya Tannistha; Hosur Ramakrishna V.;
展开▼
作者单位

Univ Mumbai UM DAE Ctr Excellence Basic Sci Kalina Campus Mumbai 400098 Maharashtra India;

Univ Mumbai UM DAE Ctr Excellence Basic Sci Kalina Campus Mumbai 400098 Maharashtra India;

TIFR Dept Chem Sci 1 Homi Bhabha Rd Mumbai 400005 Maharashtra India;

Natl Inst Technol Dept Chem Jamshedpur 831014 Bihar India;

Univ Mumbai UM DAE Ctr Excellence Basic Sci Kalina Campus Mumbai 400098 Maharashtra India;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. Measurement of H-1 NMR relaxation times in complex organic chemical systems: application of PSYCHE [J] . Kakita Veera Mohana Rao, Shukla Vaibhav Kumar, Bopardikar Mandar, RSC Advances . 2016,第102期

机译：复合有机化学体系中H-1 NMR弛豫时间的测量：心灵应用
2. Complexation of Co(DBP2)(2) by N-methylimidazole in acetonitrile: Formation constants and H-1 NMR shifts and relaxation times [J] . Wang KF., Jordan RB. Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 2000,第8期

机译：N-甲基咪唑在乙腈中形成Co（DBP2）（2）的络合物：形成常数和H-1 NMR位移和弛豫时间
3. MOLECULAR DYNAMICS OF METHOXY POLYOXYETHYLENE MACROMONOMER MICELLES IN THE ABSENCE AND PRESENCE OF SDS MICELLES USING H-1 NMR SPIN-LATTICE RELAXATION TIME MEASUREMENTS [J] . Baskar G., Mandal AB. Chemical Physics Letters . 1997,第5a6期

机译：H-1 NMR自旋格弛豫时间测量中SDS胶束存在与否的甲氧基聚氧乙烯亚甲基大分子的分子动力学
4. Measurement of longitudinal relaxation times in crowded 1H NMR spectra using one- and two-dimensional maximum quantum (MAXY) NMR spectroscopy [C] . Maili LIU Beijing conference and exhibition on instrumental analysis;BCEIA . 2001

机译：使用一维和二维最大量子（MAXY）NMR光谱测量拥挤的1H NMR光谱中的纵向弛豫时间
5. NUCLEAR MAGNETIC RESONANCE STUDIES OF CATALYSTS AND MODEL CATALYTIC SYSTEMS: BIOCHEMICAL AND INORGANIC APPLICATIONS (MINERALS, SILICON-29, OXYGEN-17, SHIELDING TENSORS, NMR). [D] . JANES, NATHAN JOHN. 1985

机译：催化剂和模型催化系统的核磁共振研究：生化和无机应用（矿物，SILICON-29，OXYGEN-17，屏蔽张量，NMR）。
6. Cross-Correlated Relaxation of Dipolar Coupling and Chemical-Shift Anisotropy in Magic-Angle Spinning R1ρ NMR Measurements: Application to Protein Backbone Dynamics Measurements [O] . Vilius Kurauskas, Emmanuelle Weber, Audrey Hessel, -1

机译：偶极耦合和化学位移各向异性的互相关弛豫在魔角旋转R1ρNMR测量中的应用：在蛋白质骨干动力学测量中的应用
7. Probing Microsecond Time Scale Dynamics in Proteins by Methyl H-1 Carr-Purcell-Meiboom-Gill Relaxation Dispersion NMR Measurements. Application to Activation of the Signaling Protein NtrC(r) [O] . Otten, Renee, Villali, Janice, Kern, Dorothee, 2010

机译：通过甲基H-1 Carr-Purcell-Meiboom-Gill弛豫弥散NMR测量来探测蛋白质中的微秒时间尺度动力学。在激活信号蛋白NtrC（r）中的应用

Measurement of H-1 NMR relaxation times in complex organic chemical systems: application of PSYCHE

摘要

著录项

相似文献

相关主题

期刊订阅