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Formation of mesoporous calcium sulfate microspheres through phase conversion in controlled calcination

机译：通过控制煅烧中的相转化形成中孔硫酸钙微球

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摘要

Calcium sulfate has been used as a biomedical material for over a century thanks to its biocompatible, biodegradable and cementitious properties. However the dense structure and low surface area of existing materials exclude its adsorption properties and restrict the applications. In this work, mesoporous calcium sulfate microspheres are prepared through topological conversion of monodisperse alpha-calcium sulfate hemihydrate (alpha-HH) microspheres under controlled calcination. The calcination process contributes to the phase conversion from alpha-HH to calcium sulfate anhydrite (AH) along with the elimination of structural water and the reduction of crystallite size, resulting in the formation of mesopores. The microspheres composed of 29.56 wt% alpha-HH and 70.44 wt% AH demonstrate a maximum surface area of 30.62 m(2) g(-1) and an ibuprofen (IBU) loading capacity of 22.44 mg g(-1), which shows a one hundred times improvement in surface area compared with traditional calcium sulfate materials. This is the first time drugs have been loaded directly to calcium sulfate particles, showing that the mesoporous calcium sulfate microspheres with uniform particle size and ordered pore structure could be a promising carrier as a biomaterial.
机译：由于其生物相容性，可生物降解和水泥性能，硫酸钙已被用作超过一个世纪的生物医学材料。然而，现有材料的致密结构和低表面积不含其吸附性能并限制应用。在这项工作中，通过在受控煅烧下通过单分散α-硫酸钙半水合物（α-HH）微球的拓扑转化来制备中孔硫酸钙微球。煅烧过程有助于将α-HH与硫酸钙无水晶（Ah）的相转化以及消除结构水和结晶尺寸的降低，从而形成中孔的形成。由29.56wt％α-hh和70.44wt％组成的微球证明了30.62m（2）g（-1）的最大表面积和22.44mg g（-1）的布洛芬（IBU）负载能力，其显示与传统的硫酸钙材料相比，表面积的改善百倍。这是第一次药物已直接向硫酸钙颗粒装载，表明具有均匀粒度和有序孔结构的中孔硫酸钙微球可以是作为生物材料的有前途的载体。

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  • 来源
    《RSC Advances》 |2016年第83期|共6页
  • 作者

    Chen Qiaoshan; Qian Mengqian; Jia Caiyun; Lin Junming; Jiang Guangming; Guan Baohong;

  • 作者单位

    Zhejiang Univ Dept Environm Engn Hangzhou 310058 Zhejiang Peoples R China;

    Zhejiang Univ Dept Environm Engn Hangzhou 310058 Zhejiang Peoples R China;

    Zhejiang Univ Dept Environm Engn Hangzhou 310058 Zhejiang Peoples R China;

    Zhejiang Univ Dept Environm Engn Hangzhou 310058 Zhejiang Peoples R China;

    Chongqing Technol &

    Business Univ Engn Res Ctr Waste Oil Recovery Technol &

    Equipme Chongqing 400067 Peoples R China;

    Zhejiang Univ Dept Environm Engn Hangzhou 310058 Zhejiang Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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