Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C-H activation

Gu Jiajia; Fang Zheng; Yang Yuhang; Yang Zhao; Wan Li; Li Xin; Wei Ping; Guo Kai

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Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C-H activation

机译：通过C-H激活铜催化的醇氧化醇对酰胺

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A one-pot oxidative amidation of both aliphatic and aromatic alcohols with N-chloramines, prepared in situ from many types of primary and secondary amines, was developed. This cross-coupling reaction integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation. And it was green, simple and convenient, which has a wide substrate scope and makes use of cheap, abundant, and easily available reagents. The practical value of this method is highlighted through the synthesis of a high-profile pharmaceutical agent, acetylprocainamide.

机译：开发了一种氧化族氧化酰胺酰胺，其用N-氯胺的原位制备的氧氯胺，从许多类型的初级和仲胺制备。该交叉偶联反应整合醇氧化和酰胺键形成，其通常分别完成，进入单一操作。它是绿色的，简单方便，具有宽的基板范围，并利用便宜，丰富，易于使用的试剂。通过合成高调的药剂，乙酰物质酰胺，突出了该方法的实际值。

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来源
《RSC Advances》 |2016年第92期|共4页
作者
Gu Jiajia; Fang Zheng; Yang Yuhang; Yang Zhao; Wan Li; Li Xin; Wei Ping; Guo Kai;
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作者单位

Nanjing Tech Univ Coll Biotechnol &

Pharmaceut Engn 30 Puzhu Rd S Nanjing 211816 Jiangsu Peoples R China;

Nanjing Tech Univ Coll Biotechnol &

Pharmaceut Engn 30 Puzhu Rd S Nanjing 211816 Jiangsu Peoples R China;

Nanjing Tech Univ Coll Biotechnol &

Pharmaceut Engn 30 Puzhu Rd S Nanjing 211816 Jiangsu Peoples R China;

China Pharmaceut Univ Sch Engn 639 Longmian Ave Nanjing 211198 Jiangsu Peoples R China;

Nanjing Tech Univ Coll Biotechnol &

Pharmaceut Engn 30 Puzhu Rd S Nanjing 211816 Jiangsu Peoples R China;

Nanjing Tech Univ Coll Biotechnol &

Pharmaceut Engn 30 Puzhu Rd S Nanjing 211816 Jiangsu Peoples R China;

Nanjing Tech Univ Coll Biotechnol &

Pharmaceut Engn 30 Puzhu Rd S Nanjing 211816 Jiangsu Peoples R China;

Nanjing Tech Univ Coll Biotechnol &

Pharmaceut Engn 30 Puzhu Rd S Nanjing 211816 Jiangsu Peoples R China;

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正文语种 eng
中图分类化学;
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1. Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C-H activation [J] . Gu Jiajia, Fang Zheng, Yang Yuhang, RSC Advances . 2016,第92期

机译：通过C-H激活铜催化的醇氧化醇对酰胺
2. Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI-TBHP: Oxidative Amidation of Aldehydes and Alcohols with N-Chloramines via C-H Activation [J] . Achar Tapas Kumar, Mal Prasenjit The Journal of Organic Chemistry . 2015,第1期

机译：使用TBAI-TBHP进行的自由基诱导的金属和无溶剂交叉偶联：醛类和醇类通过N-氯胺通过C-H活化进行氧化酰胺化
3. Radical-Induced Metal and Solvent-Free Cross-Coupling Using TBAI-TBHP: Oxidative Amidation of Aldehydes and Alcohols with N-Chloramines via C-H Activation [J] . Achar Tapas Kumar, Mal Prasenjit The Journal of Organic Chemistry . 2015,第1期

机译：使用TBAI-TBHP进行的自由基诱导的金属和无溶剂交叉偶联：醛类和醇类通过N-氯胺通过C-H活化进行氧化酰胺化
4. Catalytic Stereoselective Benzylic C-H Functionalizations by Oxidative C-H Activation and Organocatalysis [C] . Montse Guiteras Capdevila, Fides Benfatti, Luca Zoli European Symposium on Organic Chemistry . 2009

机译：催化立体选择性苄基C-H官能化氧化C-H活化与有机成分
5. Part I. One-pot synthesis of secondary alcohols and one-pot asymmetric synthesis of secondary propargylic alcohols. Part II. Redox isomerization of secondary propargylic alcohols to enones. Part III. Synthesis study towards C9-C14 fragment of (+)-discodermolide. Part IV. Asymmetric synthesis of anti, anti-stereotriad building blocks for polypropionate natural products [D] . Xie, Qiuzhe 2007

机译：第一部分：仲醇的一锅法合成和仲炔丙醇的一锅法不对称合成。第二部分仲炔丙醇的氧化还原异构化为烯酮。第三部分（+）-discodermolide C9-C14片段的合成研究。第四部分聚丙烯酸酯天然产物的抗，抗立体三环构建基的不对称合成
6. Rhodium-catalyzed oxidative amidation of allylic alcohols and aldehydes: effective conversion of amines and anilines into amides [O] . Zhao Wu, Kami L. Hull 2016

机译：铑催化的烯丙醇和醛的氧化酰胺化：胺和苯胺有效转化为酰胺
7. Highly Efficient Copper-Catalyzed Amidation of Aldehydes by C-H Activation [O] . Wang L., Fu H., Jiang Y. Y., 2008

机译：通过C-H活化进行铜的高效铜催化酰胺化

Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C-H activation

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