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首页> 外文期刊>RSC Advances >pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity
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pH-Assisted surface functionalization of selenium nanoparticles with curcumin to achieve enhanced cancer chemopreventive activity

机译：硒纳米粒子用姜黄素的pH辅助表面官能化，实现增强的癌症化学预防活性

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摘要

A facile pH-assisted method for synthesizing curcumin-functionalized selenium nanoparticles (SeNPs@Cur) with enhanced cancer chemopreventive activity is proposed in the present work. It is intriguing to observe that by controlling the pH value of the synthetic reaction system, water-insoluble Cur is successfully decorated on the surfaces of SeNPs@Cur through physical adsorption and the possible formation of Se-O bonds. Moreover, the as-prepared nanocomposites possess high drug conjugation efficiency (5.5%), good chemical stability and more uniform sizes and morphologies in comparison with bare SeNPs. Meanwhile, enhanced chemopreventive activity of SeNPs@Cur is demonstrated through the improvements of their free radical scavenging activities and the increases of their cytotoxicities against cancer cells. Cur surface decoration also increases cellular uptake of elemental Se and apoptosis in HepG2 cells. Studies on underlying mechanisms suggest that SeNPs@Cur-induced apoptosis is dependent on the activation of caspases and the overproduction of intracellular ROS. In conclusion, data herein indicate that the strategy to assemble antioxidant ligands on the surface of SeNPs is a potential way to design novel chemopreventive agents with better safety, tolerability and efficacy profiles.
机译：在本作中提出了一种用于合成姜黄素官能化硒纳米粒子（SENP @ CUR）的姜黄素官能化纳米颗粒（SENPS @ CUR）。通过控制合成反应体系的pH值来观察到，通过物理吸附和可能的SE-O键的可能形成，通过控制合成反应系统的pH值，在SENPS @ Cur的表面上成功地装饰水不溶性。此外，用裸塞彼得具有高药物缀合效率（5.5％），良好的化学稳定性和更均匀的尺寸和形态。同时，通过改善自由基清除活性和对癌细胞的细胞毒性的增加，证明了Senps @ Cur的增强的化学预防活性。 Cur表面装饰还增加了HepG2细胞中元素SE和细胞凋亡的细胞摄取。潜在机制的研究表明，森塞@ Cur诱导的细胞凋亡依赖于胱天蛋白酶的活化和细胞内RO的过量生产。总之，本文的数据表明，将抗氧化剂配体组装在森塞表面上的策略是设计具有更好安全性，耐受性和功效谱的新型化学预防剂的潜在方法。

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  • 来源
    《RSC Advances》 |2016年第76期|共11页
  • 作者

    Yu Shaoxuan; Wang Yanru; Zhang Wentao; Zhang Yuhuan; Zhu Wenxin; Liu Yingnan; Zhang Daohong; Wang Jianlong;

  • 作者单位

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

    Northwest A&

    F Univ Coll Food Sci &

    Engn Yangling 712100 Shaanxi Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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