• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >A novel sensor based on bifunctional monomer molecularly imprinted film at graphene modified glassy carbon electrode for detecting traces of moxifloxacin
【24h】

A novel sensor based on bifunctional monomer molecularly imprinted film at graphene modified glassy carbon electrode for detecting traces of moxifloxacin

机译：基于石墨烯改性玻碳电极的基于双官能单体分子印迹薄膜的新型传感器，用于检测Moxifloxacin的痕量

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A novel selective and sensitive electrochemical sensor for moxifloxacin (MFLX) detection based on bifunctional monomer molecularly imprinted polymer (MIP) membranes on a glassy carbon electrode (GCE) modified with graphene was constructed. A suspension of graphene was deposited on the GCE surface. Subsequently, a molecularly imprinted film was prepared by the electropolymerization, via cyclic voltammetry, of o-phenylenediamine and L-lysine as functional monomers in the presence of MFLX as the template molecule. A control electrode (NIP) was also prepared. The electrochemical properties of the MIP and non-molecularly imprinted polymer (NIP) sensors were investigated via cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), in which [Fe(CN)(6)](3-/4-) was used as an electrochemical active probe. The surface morphology of the imprinted film was characterized by scanning electron microscopy (SEM). The fabrication conditions that affect the performance of the imprinted sensor are discussed. Under the optimal experimental conditions, the imprinted sensor had good linear current responses to moxifloxacin concentrations in the ranges from 1.0 x 10(-9) to 1.0 x 10(-8) M and from 1.0 x 10(-8) to 5.0 x 10(-5) M, with a detection limit of 5.12 x 10(-10) M (S/N = 3). The developed sensor was successfully applied to detect moxifloxacin in tablets and human urine samples. Moreover, the fabricated sensor possessed good selectivity and stability, providing a promising tool for immunoassays and clinical applications.
机译：构建基于用石墨烯改性的玻璃状碳电极（GCE）的双官能单体分子印迹聚合物（MIP）膜的摩西氧氟沙星（MFLX）检测的新型选择性和敏感的电化学传感器。将石墨烯的悬浮液沉积在GCE表面上。随后，通过电池，通过环状伏安法，O-苯二胺和L-赖氨酸作为模板分子存在的功能单体，通过环状伏安法制备分子印迹薄膜。还制备了控制电极（NIP）。通过循环伏安法（CV）和电化学阻抗谱（EIS）研究了MIP和非分子印迹聚合物（NIP）传感器的电化学性质，其中[Fe（CN）（6）]（3- / 4-）用作电化学活性探针。通过扫描电子显微镜（SEM）表征印迹薄膜的表面形态。讨论了影响压印传感器性能的制造条件。在最佳实验条件下，印迹传感器对莫西沙星浓度的良好线性电流响应为1.0×10（-9）至1.0×10（-8）m和1.0×10（-8）至5.0 x 10 （-5）m，检出限为5.12×10（-10）m（s / n = 3）。已发发的传感器被成功地应用于检测片剂和人尿液样品中的莫西沙星。此外，制造的传感器具有良好的选择性和稳定性，为免疫测定和临床应用提供了有希望的工具。

著录项

  • 来源
    《RSC Advances》 |2016年第39期|共7页
  • 作者

    Jiang Zhiming; Li Guangyu; Zhang Mingxiao;

  • 作者单位

    Southwest Univ Sch Chem &

    Chem Engn Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing 400715 Peoples R China;

    Southwest Univ Sch Chem &

    Chem Engn Chongqing 400715 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号