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首页> 外文期刊>RSC Advances >A nanocomposite based on multi-walled carbon nanotubes grafted by molecularly imprinted poly(methacrylic acid-hemin) as a peroxidase-like catalyst for biomimetic sensing of acetaminophen
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A nanocomposite based on multi-walled carbon nanotubes grafted by molecularly imprinted poly(methacrylic acid-hemin) as a peroxidase-like catalyst for biomimetic sensing of acetaminophen

机译：基于多壁碳纳米管的纳米复合材料，其通过分子印迹聚（甲基丙烯酸 - 苯甲酸纤维酸）作为过氧化物酶样催化剂，用于对乙酰氨基酚的仿真感测

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摘要

In the present study the synthesis of a nanocomposite based on multi-walled carbon nanotubes grafted by poly(methacrylic acid-hemin) is described. The presence of functional groups in the nanocomposite was evaluated by FT-IR, while morphological, textural and thermal stability data were evaluated by means of SEM, TEM, nitrogen adsorption-desorption assays and TGA, respectively. The material was evaluated as a biomimetic and catalytic sensor toward the electrochemical determination of acetaminophen (AC) by depositing it onto a glassy carbon electrode surface. Acetaminophen has been widely used as an analgesic and antipyretics drug and for patients with a high sensitivity to aspirin; therefore the development of analytical methods for AC determination in pharmaceutical formulations is of paramount importance for quality control. The biomimetic electrochemical sensor operation is similar to that of the biosensor based on horseradish peroxidase, where the hemin in the presence of H2O2 catalyses the oxidation of acetaminophen into N-acetyl-p-benzoquinoneimine, which in turn is reduced back to AC on the electrode at a potential of -0.27 V. The variables that exert influence on the performance of the biomimetic response, including H2O2 concentration (300 mmol L-1), pH (8.0) and concentration (0.1 mol L-1) and type of buffer solution (Trizma) were investigated. Under optimized conditions the electrochemical determination of AC using multi-walled carbon nanotubes grafted by poly(methacrylic acid-hemin) immobilized on the surface of the glassy carbon electrode was carried out by square wave voltammetry (SWV), showing a limit of detection of 1.1 mmol L-1. The selectivity of material, ascribed to imprinted effect, was assured by comparison to a non-imprinted material (NIP). The proposed method was applied to AC determination in a pharmaceutical formulation, whose obtained values were very similar to those declared and statistically equal to the HPLC method, thus illustrating the feasibility of method for analysis of real samples.
机译：在本研究中基于由聚（甲基丙烯酸 - 氯高铁血红素）接枝的多壁碳纳米管的纳米复合材料的合成进行说明。官能团在纳米复合材料中的存在通过FT-IR进行评价，而形态，质地和热稳定性数据通过SEM，TEM，氮吸附 - 脱附测定和TGA，分别进行评价。的材料被评价为通过沉积它放到玻碳电极表面朝向所述电化学测定对乙酰氨基酚（AC）的仿生和催化传感器。对乙酰氨基酚已被广泛地用作止痛剂和退热药的药物和患者对阿司匹林具有高敏感性;因此对于AC判定在药物制剂中的分析方法的开发是用于质量控制至关重要。仿生电化学传感器的操作是类似的生物传感器的基础上辣根过氧化物酶，其中过氧化氢的存在下，氯高铁血红素催化乙酰氨基酚氧化成N-乙酰基 - 对 - 苯醌亚胺，这反过来又降低回AC在电极上在-0.27伏的电位的变量上的仿生响应的性能施加影响，包括H 2 O 2浓度（300毫摩尔L-1），pH值（8.0）和浓度（0.1摩尔L-1）和缓冲液类型（氨基丁三醇）进行了调查。在优化的条件下，使用由聚接枝多壁碳纳米管（甲基丙烯酸 - 氯高铁血红素）固定在玻碳电极的表面上的AC的电化学测定是通过方波伏安法（SWV）进行，表示检测的1.1的极限毫摩尔L-1。材料的选择性，归因于印记的效果，是通过比较一个非压印材料（NIP）保证。所提出的方法应用于AC判定在药物制剂中，其得到的值是非常相似的声明和统计学等于HPLC方法，从而示出了用于实际样品的分析方法的可行性。

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  • 来源
    《RSC Advances》 |2016年第34期|共10页
  • 作者

    Moretti Ederson dos Santos; Giarola Juliana de Fatima; Kuceki Michele; Prete Maiyara Carolyne; Pereira Arnaldo Cesar; Teixeira Tarley Cesar Ricardo;

  • 作者单位

    Univ Estadual Londrina Dept Quim Ctr Ciencias Exatas Rodovia Celso Garcia Cid PR 445 Km 380 BR-86050482 Londrina PR Brazil;

    Univ Fed Sao Joao del Rei UFSJ Dept Ciencias Nat Campus Dom Bosco Praca Dom Helvecio 74 BR-36301160 Sao Joao Del Rei MG Brazil;

    Univ Estadual Londrina Dept Quim Ctr Ciencias Exatas Rodovia Celso Garcia Cid PR 445 Km 380 BR-86050482 Londrina PR Brazil;

    Univ Estadual Londrina Dept Quim Ctr Ciencias Exatas Rodovia Celso Garcia Cid PR 445 Km 380 BR-86050482 Londrina PR Brazil;

    Univ Fed Sao Joao del Rei UFSJ Dept Ciencias Nat Campus Dom Bosco Praca Dom Helvecio 74 BR-36301160 Sao Joao Del Rei MG Brazil;

    Univ Estadual Londrina Dept Quim Ctr Ciencias Exatas Rodovia Celso Garcia Cid PR 445 Km 380 BR-86050482 Londrina PR Brazil;

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