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Chemometrics strategy coupled with high resolution mass spectrometry for analyzing and interpreting comprehensive metabolomic characterization of hyperlipemia

机译：化学计量策略与高分辨率质谱分析和解释综合性高脂血症的综合性新代谢特征

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摘要

Hyperlipidemia (HLP) is a metabolic disorder which is characterized by a disturbance in lipid metabolism and is a primary risk factor for cardiovascular disease and atherosclerosis. Patients who were diagnosed with hyperlipidemia are usually with a serious dyslipidemia, which can be evaluated by current clinical markers such as triglyceride, total cholesterol, low density lipoprotein cholesterol, and high-density lipoprotein. Metabolic profiling has great potential to help the diagnosis and prognosis of hyperlipidemia patients in an earlier stage. To explore the metabolic profiling, we used ultraperformance liquid chromatography mass spectrometry, monitored the metabolites' alterations and impaired pathways in HLP patients. Of note, a total of 37 serum metabolites from HLP patients were tentatively identified. Furthermore, they were involved in 11 pathways such as linoleic acid metabolism, glycerophospholipid metabolism, terpenoid backbone biosynthesis, sphingolipid metabolism, glycosylphosphatidylinositolanchor biosynthesis, steroid hormone biosynthesis, arachidonic acid metabolism, pentose and glucuronate interconversions, starch and sucrose metabolism, glycerolipid metabolism and purine metabolism. These results provide potential biomarkers for early risk assessment of HLP and offer further insights into the complex metabolic pathway changes in HLP. They also suggest the distinction of utilizing UPLC-Q-TOF-MS for exploring metabolic characterization of HLP patients.
机译：高脂血症（HLP）是一种代谢紊乱，其特征在于脂质代谢的干扰，是心血管疾病和动脉粥样硬化的主要危险因素。被诊断出患有高脂血症的患者通常具有严重的血脂血症，其可以通过当前临床标志物如甘油三酯，总胆固醇，低密度脂蛋白胆固醇和高密度脂蛋白进行评估。代谢分析有很大的潜力，有助于帮助在早期阶段的高脂血症患者的诊断和预后。为了探索代谢分析，我们使用超细液相色谱质谱法，监测代谢物的改变和HLP患者的途径受损。值得注意的是，暂时鉴定了来自HLP患者的37种血清代谢物。此外，它们涉及11条途径，如亚油酸代谢，甘油磷脂代谢，三萜骨架生物合成，鞘脂代谢，糖基磷脂酰胺型糖和糖苷，类固醇激素生物合成，花生素代谢，戊糖和葡糖酸酯互联，淀粉和蔗糖代谢，甘油脂代谢和嘌呤代谢。 。这些结果为HLP的早期风险评估提供了潜在的生物标志物，并进一步了解HLP中复杂的代谢途径变化。他们还建议利用UPLC-Q-TOF-MS进行探索HLP患者的代谢表征的区别。

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  • 来源
    《RSC Advances》 |2016年第113期|共10页
  • 作者

    Zhao Qiqi; Zhang Aihua; Zong Wenjing; An Na; Zhang Huamin; Luan Yihan; Cao Hongxin; Sun Hui; Wang Xijun;

  • 作者单位

    Heilongjiang Univ Chinese Med Chinmed Res Ctr TCM State Adm Natl TCM Key Lab Serum Pharmacochem SinoUS Chinmed Technol Cooperat Ctr Metabol Lab Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Chinmed Res Ctr TCM State Adm Natl TCM Key Lab Serum Pharmacochem SinoUS Chinmed Technol Cooperat Ctr Metabol Lab Heping Rd 24 Harbin 150040 Peoples R China;

    China Acad Chinese Med Sci Southern St Dongzhimen 16 Beijing 100700 Peoples R China;

    Heilongjiang Univ Chinese Med Chinmed Res Ctr TCM State Adm Natl TCM Key Lab Serum Pharmacochem SinoUS Chinmed Technol Cooperat Ctr Metabol Lab Heping Rd 24 Harbin 150040 Peoples R China;

    China Acad Chinese Med Sci Southern St Dongzhimen 16 Beijing 100700 Peoples R China;

    China Acad Chinese Med Sci Southern St Dongzhimen 16 Beijing 100700 Peoples R China;

    Heilongjiang Univ Chinese Med Chinmed Res Ctr TCM State Adm Natl TCM Key Lab Serum Pharmacochem SinoUS Chinmed Technol Cooperat Ctr Metabol Lab Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Chinmed Res Ctr TCM State Adm Natl TCM Key Lab Serum Pharmacochem SinoUS Chinmed Technol Cooperat Ctr Metabol Lab Heping Rd 24 Harbin 150040 Peoples R China;

    Heilongjiang Univ Chinese Med Chinmed Res Ctr TCM State Adm Natl TCM Key Lab Serum Pharmacochem SinoUS Chinmed Technol Cooperat Ctr Metabol Lab Heping Rd 24 Harbin 150040 Peoples R China;

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