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Preparation of pH- and magnetism-responsive sodium alginate/Fe3O4@HNTs nanocomposite beads for controlled release of granulysin

机译：用于控制萌生素控制释放的pH-磁性响应钠藻酸钠/ Fe3O4的制备

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摘要

The burst release of drug molecules from natural biopolymer-based hydrogels is a common issue in the field of controlled drug delivery systems. pH-and magnetism-responsive sodium alginate/Fe3O4@HNTs nanocomposite beads for controlled release of granulysin were prepared. Fe3O4@HNTs were prepared by growth of Fe3O4 nanoparticles on the surface of HNTs via solvothermal reactions. Then, the SA/Fe3O4@HNTs-granulysin nanocomposite beads were prepared by sol-gel transition of the SA-granulysin aqueous solution with homogeneously dispersed Fe3O4@HNTs. The nanocomposite beads were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. In addition, the factors, e.g., the concentration of SA, weight ratio of Fe3O4@HNTs to SA and weight ratio of FeCl3 center dot 6H(2)O to HNTs, influencing granulysin loading and controlled release behavior were systematically studied. The entrapment efficiency was enhanced to 61.4% and the burst release of granulysin was overcome by introducing appropriate amounts of HNTs and the Fe3O4 nanoparticles. Granulysin was released at a steady rate in pH 7.4 PB owing to the synergistic effects of SA, HNTs and the Fe3O4 nanoparticles. The release kinetics of granulysin from the nanocomposite beads follows the Higuchi model. HNTs and the Fe3O4 nanoparticles formed additional crosslinkages in the nanocomposite beads, which changed the swelling behaviors of the beads, and then improved the controlled release behaviors of the model drug molecules.
机译：来自天然生物聚合物的水凝胶的药物分子的突发释放是受控药物递送系统领域的常见问题。制备PH-磁性响应钠/ Fe3O4颗粒蛋白的控制释放的纳米复合材料珠粒。通过通过溶剂热反应在HNT表面的Fe3O4纳米颗粒的生长来制备Fe3O4 @ HNT。然后，通过用均匀分散的Fe3O4 @ HNT制备SA / Fe3O4纳米复合珠粒制备SA-甘油蛋白素水溶液的溶胶 - 凝胶转变。通过傅里叶变换红外光谱和扫描电子显微镜表征纳米复合材料珠粒。另外，系统地研究了因素，例如SA的浓度，Fe3O4 @ HNT的浓度和FECL3中心点6H（2）O对HNT的SA和重量比，影响粒瘤负载和受控释放行为的系统。夹带效率增强至61.4％，通过引入适量的HNT和Fe 3 O 4纳米颗粒来克服颗粒蛋白的突发释放。由于SA，HNT和Fe3O4纳米颗粒的协同作用，颗粒蛋白以pH 7.4pb的稳定速率释放。从纳米复合珠粒中萌发动力学遵循HIGUCHI模型。 HNT和Fe3O4纳米颗粒在纳米复合珠中形成额外的交联剂，其改变了珠子的肿胀行为，然后改善了模型药物分子的受控释放行为。

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  • 来源
    《RSC Advances》 |2016年第113期|共7页
  • 作者

    Xu Xianghong; Qu Tao; Fan Ling; Chen Xiaomei; Gao Men; Zhang Junping; Guo Tiankang;

  • 作者单位

    Gansu Prov Hosp Dept Biotherapy Ctr Lanzhou 730000 Peoples R China;

    Gansu Prov Hosp Dept Biotherapy Ctr Lanzhou 730000 Peoples R China;

    Chinese Acad Sci Lanzhou Inst Chem Phys Key Lab Clay Mineral Appl Res Gansu Prov Lanzhou 730000 Peoples R China;

    Gansu Prov Hosp Dept Biotherapy Ctr Lanzhou 730000 Peoples R China;

    Gansu Prov Hosp Dept Biotherapy Ctr Lanzhou 730000 Peoples R China;

    Chinese Acad Sci Lanzhou Inst Chem Phys Key Lab Clay Mineral Appl Res Gansu Prov Lanzhou 730000 Peoples R China;

    Gansu Prov Hosp Lanzhou 730000 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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