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首页> 外文期刊>RSC Advances >Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics
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Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics

机译：果胶叶酸缀合金纳米粒子的绿色合成作为癌症治疗的还原/稳定剂

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In the present study pectin, a natural polysaccharide was employed for the one pot aqueous synthesis of gold nanoparticles (GNPs). Pectin acted at the same time as both a reducing and stabilizing agent. The formation of pectin reduced GNPs (Pec-GNPs) was confirmed by using a UV-visible spectrophotometer, with a characteristic surface plasmon resonance (SPR) band at 527 nm. EDS analysis proved the presence of gold in the sample. The spherical morphology and crystalline nature of the Pec-GNPs was demonstrated by TEM analysis. The FTIR spectrum revealed the capping of pectin on the surface of the synthesised GNPs. Furthermore, the Pec-GNPs are found to be stable at different pH and electrolytic conditions. In vivo safety of the Pec-GNPs was established through zebra fish toxicity studies. The cationic drug doxorubicin was successfully loaded onto the synthesized anionic Pec-GNPs by an ionic complexation interaction. In vitro release studies confirmed the pH dependent sustained release of the doxorubicin. Doxorubicin loaded Pec-GNPs exhibited enhanced in vitro cytotoxicity on breast cancer cells compared to free doxorubicin, demonstrating that Pec-GNPs are efficient vehicles for the delivery of doxorubicin. Furthermore, chitosan coupled with folic acid (FA) was decorated with Pec-GNPs-DOX as a nanocarrier to improve the targeting and enhance the drug delivery to target cancer tissues by folic acid receptormediated endocytosis. It was concluded that the FA@Pec-GNPs-DOX were biocompatible and suitable for anti-cancer drug delivery, and were potentially promising as a new therapeutic system for cancer treatment.
机译：在本研究中，使用天然多糖用于金纳米颗粒（GNP）的一个罐水合合成。果胶与还原和稳定剂同时作用。通过使用UV可见分光光度计确认果胶的形成减少了GNPS（PEC-GNP），其中特征表面等离子体共振（SPR）带为527nm。 EDS分析证明了样品中的黄金存在。通过TEM分析证明了PEC-GNP的球形形态和结晶性质。 FTIR光谱揭示了合成的GNPS表面上果胶的封盖。此外，发现PEC-GNP在不同的pH和电解条件下是稳定的。通过斑马鱼毒性研究建立了PEC-GNP的体内安全性。通过离子络合相互作用成功地将阳离子药物DOXOXORUBICIN成功装载到合成的阴离子PEC-GNP上。体外释放研究证实了多柔比星的pH依赖性释放。与游离的多柔比星相比，Doxorubicin负载的PEC-GNP在乳腺癌细胞上表现出增强的体外细胞毒性，表明PEC-GNP是用于递送多柔比星的有效车辆。此外，壳聚糖与叶酸（Fa）偶联用PEC-GNPS-DOX作为纳米载体装饰，以通过叶酸接受内吞作用改善靶向并增强药物递送以靶向癌组织。得出结论是，FA @ PEC-GNPS-DOX是生物相容的，适用于抗癌药物递送，并且可能是作为癌症治疗的新治疗系统。

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