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首页> 外文期刊>RSC Advances >Surface functionalization of natural lignin isolated from Aloe barbadensis Miller biomass by atom transfer radical polymerization for enhanced anticancer efficacy
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Surface functionalization of natural lignin isolated from Aloe barbadensis Miller biomass by atom transfer radical polymerization for enhanced anticancer efficacy

机译：用原子传递自由基聚合从芦荟Barbadensis米勒生物量分离的天然木质素的表面官能化，以增强抗癌功效

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摘要

Lignin (LIG), one of the major natural polymers in the biomass is widely used for various industrial and biomedical applications, mainly in its modified form of grafted lignin. The present study focuses on the isolation of lignin from Aloe barbadensis Miller by a microwave extraction technique and its applicability as a medicinal biomass. The isolated lignin was used for the synthesis of a drug carrier by grafting with methacrylate (MA). Lignin grafted methacrylate was synthesised (LIG-g-MA) via atom transfer radical polymerization (ATRP). 5-Fluorouracil (5-FU) was used as a model cancer drug and it was encapsulated on the hollow nanocarrier by the emulsion/solvent evaporation technique. While NMR spectroscopy elucidates the structure of the isolated lignin, FT-IR and XRD techniques address the binding nature and crystalline character of 5-FU loaded carrier. The surface morphology of the isolated lignin, grafted lignin and drug-loaded carrier was confirmed with SEM and TEM techniques. The encapsulation efficiency and in vitro drug release were studied to determine the efficiency of the carrier. The cell viability and cytotoxicity effect of 5-FU loaded on LIG-g-MA and unloaded LIG-g-MA were performed against MCF-7 and VERO cell lines. In short, the modified natural lignin based on LIG-g-MA hollow-nanofibrous material has been shown to be a potentially useful biocompatible nanocarrier in chemotherapy for cancer treatment.
机译：Lignin（Lig），生物量中的主要天然聚合物之一广泛用于各种工业和生物医学应用，主要以其改良的嫁接木质素形式。本研究专注于通过微波萃取技术从芦荟Barbadensis Miller中分离木质素，其作为药物生物量的适用性。分离的木质素通过用甲基丙烯酸酯（MA）接枝来合成药物载体。通过原子转移自由基聚合（ATRP）合成木质素接枝甲基丙烯酸酯（LIG-G-MA）。 5-氟尿嘧啶（5-FU）用作模型癌药物，通过乳液/溶剂蒸发技术包封在中空纳米载体上。虽然NMR光谱阐明了分离的木质素，FT-IR和XRD技术的结构，用于解决5-FU负载载体的结合性质和结晶特性。用SEM和TEM技术证实了分离的木质素，接枝木质素和药物负载载体的表面形态。研究了封装效率和体外药物释放以确定载体的效率。对MCF-7和VERO细胞系进行了5-FU的细胞活力和卸载的LIG-G-MA的细胞活力和细胞毒性作用。总之，基于LIG-G-MA中空纳米纤维材料的改性天然木质素已被证明是在癌症化疗治疗潜在有用的生物相容的纳米载体。

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