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Influence of a non-biodegradable porous structure on bone repair

机译：非生物降解多孔结构对骨修复的影响

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摘要

Pore and interconnection size are two key structural parameters for bone tissue engineering scaffolds. In the present study, four hydroxyapatite (HA) bioceramic scaffolds with similar pore size (500-600 mu m) but different interconnection sizes (100, 120, 150 and 200 mm), and three HA scaffolds with similar interconnection size (120 mu m) but different pore sizes (400-500, 500-600 and 600-700 mu m) were implanted into distal femoral condyle defects for 72 rabbits. The results showed that volume of new bone increased proportionally to the interconnection size. However, significant differences between interconnection size groups were only observed at week 24. Smaller pore size showed significantly more new bone formation at week 4, whereas no significant differences between the three pore size groups were found at weeks 12 and 24. In conclusion, large interconnection size facilitates new bone formation and a minimum size of 120 mu m is recommended. Although small pore size improves bone ingrowth at early time points, pore size has limited impact on bone ingrowth later.
机译：孔和互连尺寸是骨组织工程支架的两个关键结构参数。在本研究中，四种羟基磷灰石（HA）生物陶瓷支架具有相似的孔径（500-600μm）但不同的互连尺寸（100,120,150和200mm），以及具有相似互连尺寸的三个HA支架（120μm ）但不同的孔径（400-500,500-600和600-700 mu m）植入远端股骨髁缺损，以获得72只兔子。结果表明，新骨的体积与互连尺寸成比例地增加。然而，互连尺寸基团之间仅在第24周观察到的显着差异。第4周，较小的孔径显示出更高的新骨形成，而在12周和24周内发现了三个孔径组之间的显着差异。总之，大互连尺寸有助于新的骨骼形成，建议最小尺寸为120 mu m。虽然小孔径在早期孔径上改善了骨骼的骨骼，但孔径在后面对骨骼的影响有限。

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  • 来源
    《RSC Advances》 |2016年第84期|共7页
  • 作者

    Lu Xiao; Wang Yingjun; Jin Fangchun;

  • 作者单位

    South China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510641 Guangdong Peoples R China;

    South China Univ Technol Sch Mat Sci &

    Engn Guangzhou 510641 Guangdong Peoples R China;

    Shanghai Jiao Tong Univ Sch Med Xin Hua Hosp Dept Pediat Orthopaed Shanghai 200092 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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