Highly efficient regio and diastereoselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties

Ramesh Pambala; Rao Kadiyala Srinivasa; Trivedi Rajiv; Kumar B. Sudheer; Prakasham R. S.; Sridhar B.

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Highly efficient regio and diastereoselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties

机译：高效的官能化双螺氧吲哚组合和抗菌性能的高效序列和非对映选择性合成及其抗菌性能

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A simple, efficient, regioselective and diastereoselective method has been developed for the synthesis of diversely functionalized spirooxindole-pyrrolidines using 0.5 mol% of ceric ammonium nitrate in aqueous medium. All the new compounds are tested for in vitro antimicrobial activity. All the synthesized products have shown good antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Micrococcus luteus (Gram-positive organisms), Salmonella paratyphi, Pseudomonas aeruginosa and Salmonella typhi (Gram-negative organism).

机译：已经开发了一种简单，高效，区域选择性和非对映选择的方法，用于在水性介质中使用0.5mol％的硝酸铈铵硝酸铵合成多变官能化螺氧吲哚-吡咯烷。所有新化合物都经过体外抗微生物活性测试。所有合成的产品都显示出对枯草芽孢杆菌，金黄色葡萄球菌，微胶囊（革兰氏阴性生物），沙门氏菌帕拉替氏菌，假鼠铜绿假单胞菌和沙门氏菌（革兰氏阴性生物）的良好抗菌活性。

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来源
《RSC Advances》 |2016年第32期|共7页
作者
Ramesh Pambala; Rao Kadiyala Srinivasa; Trivedi Rajiv; Kumar B. Sudheer; Prakasham R. S.; Sridhar B.;
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作者单位

Indian Inst Chem Technol CSIR Inorgan &

Phys Chem Div Hyderabad 500007 Andhra Pradesh India;

Indian Inst Chem Technol CSIR Inorgan &

Phys Chem Div Hyderabad 500007 Andhra Pradesh India;

Indian Inst Chem Technol CSIR Inorgan &

Phys Chem Div Hyderabad 500007 Andhra Pradesh India;

Indian Inst Chem Technol CSIR Bio Engn &

Environm Ctr Hyderabad 500007 Andhra Pradesh India;

Indian Inst Chem Technol CSIR Bio Engn &

Environm Ctr Hyderabad 500007 Andhra Pradesh India;

Indian Inst Chem Technol CSIR Lab Xray Crystallog Hyderabad 500007 Andhra Pradesh India;

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正文语种 eng
中图分类化学;
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1. Highly efficient regio and diastereoselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties [J] . Ramesh Pambala, Rao Kadiyala Srinivasa, Trivedi Rajiv, RSC Advances . 2016,第32期

机译：高效的官能化双螺氧吲哚组合和抗菌性能的高效序列和非对映选择性合成及其抗菌性能
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机译：高效，单罐合成新的双螺氧吲哚吲哚，通过PEG-400中的序列多组分反应作为可生物降解的溶剂

Highly efficient regio and diastereoselective synthesis of functionalized bis-spirooxindoles and their antibacterial properties

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